Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters

Abstract To investigate the relationship between geometrical changes of retinal vessels and diabetic peripheral neuropathy (DPN), and to determine the effectiveness of retinal vascular geometry analysis and vibration perception threshold (VPT) for DPN assessment. Type 2 diabetes patients (n = 242) w...

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Autores principales:	Guotao Hu, Hongmei Wu, Lei Kuang, Benny Chung-Ying Zee, Ying Huang, Zhen Huang, Li He, Yuanhong Zeng, Yongbo Gao, Hailan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b8e308bff8744a880d78ae67e930e0f
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spelling	oai:doaj.org-article:9b8e308bff8744a880d78ae67e930e0f2021-12-02T17:04:07ZClinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters10.1038/s41598-021-85831-02045-2322https://doaj.org/article/9b8e308bff8744a880d78ae67e930e0f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85831-0https://doaj.org/toc/2045-2322Abstract To investigate the relationship between geometrical changes of retinal vessels and diabetic peripheral neuropathy (DPN), and to determine the effectiveness of retinal vascular geometry analysis and vibration perception threshold (VPT) for DPN assessment. Type 2 diabetes patients (n = 242) were categorized by stage of DPN. VPT and fundus photography was performed to obtain retinal vascular geometry parameters. The risk factors for DPN and the correlation between DPN stages were analyzed. The efficiency of the retinal vascular geometric parameters obtained with VPT as a diagnostic tool for DPN was examined. Stages of DPN showed a linear correlation with VPT (r = 0.818), central retinal vein equivalent (CRVE) (r = 0.716), and fractal dimension arterioles (DFa) (r = − 0.769). VPT, CRVE, DFa, and fractal dimension veins (DFv) showed high sensitivity (80%, 55%, 82%, and 67%, respectively) and specificity (92%, 93%, 82%, and 80%, respectively) for DPN diagnosis. Good agreement was observed between combined use of geometric parameters (CRVE, DFa and DFv) and VPT (Kappa value 0.430). The detection rate of DPN with combined use of geometric parameters of retinal vessels (64.88%) was significantly higher than that with use of VPT (47.52%). Retinal vascular geometry changes demonstrated significant correlation with DPN severity. VPT, CRVE, DFa, and DFv may provide insights for understanding DPN.Guotao HuHongmei WuLei KuangBenny Chung-Ying ZeeYing HuangZhen HuangLi HeYuanhong ZengYongbo GaoHailan WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guotao Hu Hongmei Wu Lei Kuang Benny Chung-Ying Zee Ying Huang Zhen Huang Li He Yuanhong Zeng Yongbo Gao Hailan Wang Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
description	Abstract To investigate the relationship between geometrical changes of retinal vessels and diabetic peripheral neuropathy (DPN), and to determine the effectiveness of retinal vascular geometry analysis and vibration perception threshold (VPT) for DPN assessment. Type 2 diabetes patients (n = 242) were categorized by stage of DPN. VPT and fundus photography was performed to obtain retinal vascular geometry parameters. The risk factors for DPN and the correlation between DPN stages were analyzed. The efficiency of the retinal vascular geometric parameters obtained with VPT as a diagnostic tool for DPN was examined. Stages of DPN showed a linear correlation with VPT (r = 0.818), central retinal vein equivalent (CRVE) (r = 0.716), and fractal dimension arterioles (DFa) (r = − 0.769). VPT, CRVE, DFa, and fractal dimension veins (DFv) showed high sensitivity (80%, 55%, 82%, and 67%, respectively) and specificity (92%, 93%, 82%, and 80%, respectively) for DPN diagnosis. Good agreement was observed between combined use of geometric parameters (CRVE, DFa and DFv) and VPT (Kappa value 0.430). The detection rate of DPN with combined use of geometric parameters of retinal vessels (64.88%) was significantly higher than that with use of VPT (47.52%). Retinal vascular geometry changes demonstrated significant correlation with DPN severity. VPT, CRVE, DFa, and DFv may provide insights for understanding DPN.
format	article
author	Guotao Hu Hongmei Wu Lei Kuang Benny Chung-Ying Zee Ying Huang Zhen Huang Li He Yuanhong Zeng Yongbo Gao Hailan Wang
author_facet	Guotao Hu Hongmei Wu Lei Kuang Benny Chung-Ying Zee Ying Huang Zhen Huang Li He Yuanhong Zeng Yongbo Gao Hailan Wang
author_sort	Guotao Hu
title	Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
title_short	Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
title_full	Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
title_fullStr	Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
title_full_unstemmed	Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
title_sort	clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b8e308bff8744a880d78ae67e930e0f
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Clinical study of diabetic peripheral neuropathy screening by retinal vascular geometric parameters

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