Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review

Background: Regenerative endodontics aims to restore normal pulp function in necrotic and infected teeth, restoring protective functions, such as innate pulp immunity, pulp repair through mineralization, and pulp sensibility. The aim of this systematic review was to assess the dentin regeneration ef...

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Autores principales:	Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	direct pulp capping dentin regeneration dentin-bridge formation reparative dentin calcium hydroxide mineral trioxide aggregate Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/9b8e7c00aadc47a297725a878f4562c2
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spelling	oai:doaj.org-article:9b8e7c00aadc47a297725a878f4562c22021-11-25T18:13:47ZEffectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review10.3390/ma142268111996-1944https://doaj.org/article/9b8e7c00aadc47a297725a878f4562c22021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/6811https://doaj.org/toc/1996-1944Background: Regenerative endodontics aims to restore normal pulp function in necrotic and infected teeth, restoring protective functions, such as innate pulp immunity, pulp repair through mineralization, and pulp sensibility. The aim of this systematic review was to assess the dentin regeneration efficacy of direct pulp capping (DPC) biomaterials. Methods: The literature published between 2005 and 2021 was searched by using PubMed, Web of Science, Science Direct, Google Scholar, and Scopus databases. Clinical controlled trials, randomized controlled trials, and animal studies investigating DPC outcomes or comparing different capping materials after pulp exposure were included in this systematic review. Three independent authors performed the searches, and information was extracted by using a structured data format. Results: A total of forty studies (21 from humans and 19 from animals) were included in this systemic review. Histological examinations showed complete/partial/incomplete dentin bridge/reparative dentin formation during the pulp healing process at different follow-up periods, using different capping materials. Conclusions: Mineral trioxide aggregate (MTA) and Biodentine can induce dentin regeneration when applied over exposed pulp. This systematic review can conclude that MTA and its variants have better efficacy in the DPC procedure for dentin regeneration.Ermin NieJiali YuRui JiangXiangzhen LiuXiang LiRafiqul IslamMohammad Khursheed AlamMDPI AGarticledirect pulp cappingdentin regenerationdentin-bridge formationreparative dentincalcium hydroxidemineral trioxide aggregateTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6811, p 6811 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	direct pulp capping dentin regeneration dentin-bridge formation reparative dentin calcium hydroxide mineral trioxide aggregate Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	direct pulp capping dentin regeneration dentin-bridge formation reparative dentin calcium hydroxide mineral trioxide aggregate Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Ermin Nie Jiali Yu Rui Jiang Xiangzhen Liu Xiang Li Rafiqul Islam Mohammad Khursheed Alam Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
description	Background: Regenerative endodontics aims to restore normal pulp function in necrotic and infected teeth, restoring protective functions, such as innate pulp immunity, pulp repair through mineralization, and pulp sensibility. The aim of this systematic review was to assess the dentin regeneration efficacy of direct pulp capping (DPC) biomaterials. Methods: The literature published between 2005 and 2021 was searched by using PubMed, Web of Science, Science Direct, Google Scholar, and Scopus databases. Clinical controlled trials, randomized controlled trials, and animal studies investigating DPC outcomes or comparing different capping materials after pulp exposure were included in this systematic review. Three independent authors performed the searches, and information was extracted by using a structured data format. Results: A total of forty studies (21 from humans and 19 from animals) were included in this systemic review. Histological examinations showed complete/partial/incomplete dentin bridge/reparative dentin formation during the pulp healing process at different follow-up periods, using different capping materials. Conclusions: Mineral trioxide aggregate (MTA) and Biodentine can induce dentin regeneration when applied over exposed pulp. This systematic review can conclude that MTA and its variants have better efficacy in the DPC procedure for dentin regeneration.
format	article
author	Ermin Nie Jiali Yu Rui Jiang Xiangzhen Liu Xiang Li Rafiqul Islam Mohammad Khursheed Alam
author_facet	Ermin Nie Jiali Yu Rui Jiang Xiangzhen Liu Xiang Li Rafiqul Islam Mohammad Khursheed Alam
author_sort	Ermin Nie
title	Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
title_short	Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
title_full	Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
title_fullStr	Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
title_full_unstemmed	Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
title_sort	effectiveness of direct pulp capping bioactive materials in dentin regeneration: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9b8e7c00aadc47a297725a878f4562c2
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_version_	1718411453304668160

Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review

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