Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program

Herpes simplex virus 1 (HSV-1) induces major reprogramming of the host cell environment. Here, the authors profile the transcriptomes of individual HSV-1-infected human fibroblasts and provide evidence of an antiviral program mediated by the activation of the host transcription factor NRF2.

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Autores principales:	Emanuel Wyler, Vedran Franke, Jennifer Menegatti, Christine Kocks, Anastasiya Boltengagen, Samantha Praktiknjo, Barbara Walch-Rückheim, Jens Bosse, Nikolaus Rajewsky, Friedrich Grässer, Altuna Akalin, Markus Landthaler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b9106fe09bb41628a077aaba85373ab
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spelling	oai:doaj.org-article:9b9106fe09bb41628a077aaba85373ab2021-12-02T14:39:56ZSingle-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program10.1038/s41467-019-12894-z2041-1723https://doaj.org/article/9b9106fe09bb41628a077aaba85373ab2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12894-zhttps://doaj.org/toc/2041-1723Herpes simplex virus 1 (HSV-1) induces major reprogramming of the host cell environment. Here, the authors profile the transcriptomes of individual HSV-1-infected human fibroblasts and provide evidence of an antiviral program mediated by the activation of the host transcription factor NRF2.Emanuel WylerVedran FrankeJennifer MenegattiChristine KocksAnastasiya BoltengagenSamantha PraktiknjoBarbara Walch-RückheimJens BosseNikolaus RajewskyFriedrich GrässerAltuna AkalinMarkus LandthalerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emanuel Wyler Vedran Franke Jennifer Menegatti Christine Kocks Anastasiya Boltengagen Samantha Praktiknjo Barbara Walch-Rückheim Jens Bosse Nikolaus Rajewsky Friedrich Grässer Altuna Akalin Markus Landthaler Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
description	Herpes simplex virus 1 (HSV-1) induces major reprogramming of the host cell environment. Here, the authors profile the transcriptomes of individual HSV-1-infected human fibroblasts and provide evidence of an antiviral program mediated by the activation of the host transcription factor NRF2.
format	article
author	Emanuel Wyler Vedran Franke Jennifer Menegatti Christine Kocks Anastasiya Boltengagen Samantha Praktiknjo Barbara Walch-Rückheim Jens Bosse Nikolaus Rajewsky Friedrich Grässer Altuna Akalin Markus Landthaler
author_facet	Emanuel Wyler Vedran Franke Jennifer Menegatti Christine Kocks Anastasiya Boltengagen Samantha Praktiknjo Barbara Walch-Rückheim Jens Bosse Nikolaus Rajewsky Friedrich Grässer Altuna Akalin Markus Landthaler
author_sort	Emanuel Wyler
title	Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
title_short	Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
title_full	Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
title_fullStr	Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
title_full_unstemmed	Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
title_sort	single-cell rna-sequencing of herpes simplex virus 1-infected cells connects nrf2 activation to an antiviral program
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9b9106fe09bb41628a077aaba85373ab
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Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program

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