The efficacy of antipsychotics for prolonged delirium with renal dysfunction
Satoko Asano, Yasuto Kunii, Hiroshi Hoshino, Yusuke Osakabe, Tetsuya Shiga, Shuntaro Itagaki, Itaru Miura, Hirooki Yabe Department of Neuropsychiatry, School of Medicine Fukushima Medical University, Fukushima, Japan Aim: Delirium is commonly encountered in daily clinical practice. To identify pre...
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Dove Medical Press
2017
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oai:doaj.org-article:9b916fb992424d63bb8cfa9ae08112702021-12-02T01:11:54ZThe efficacy of antipsychotics for prolonged delirium with renal dysfunction1178-2021https://doaj.org/article/9b916fb992424d63bb8cfa9ae08112702017-11-01T00:00:00Zhttps://www.dovepress.com/the-efficacy-of-antipsychotics-for-prolonged-delirium-with-renal-dysfu-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Satoko Asano, Yasuto Kunii, Hiroshi Hoshino, Yusuke Osakabe, Tetsuya Shiga, Shuntaro Itagaki, Itaru Miura, Hirooki Yabe Department of Neuropsychiatry, School of Medicine Fukushima Medical University, Fukushima, Japan Aim: Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization.Methods: We extracted all new inpatients (n=523) consulted for psychiatric symptoms at Fukushima Medical University Hospital between October 2011 and September 2013. We selected 203 inpatients with delirium diagnosed by psychiatrists. We analyzed data from 177 inpatients with delirium who received psychiatric medication. We defined an “early improvement group” in which delirium resolved in ≤3 days after starting psychiatric medication, and a “prolonged group” with delirium lasting for >3 days. Among the 83 inpatients with renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2), we defined an “early improvement group with renal dysfunction” in which delirium resolved in ≤3 days after starting psychiatric medication and a “prolonged group with renal dysfunction” with delirium lasting for >3 days. We then examined differences between groups for different categorical variables.Results: Dose of antipsychotic medication at end point was significantly lower in the prolonged group with renal dysfunction than in the early improvement group with renal dysfunction.Conclusion: The results suggest that maintaining a sufficient dose of antipsychotics from an early stage may prevent prolongation of delirium even in inpatients with renal dysfunction. Keywords: antipsychotic, prolonged delirium, chronic kidney disease, pharmacokinetics Asano SKunii YHoshino HOsakabe YShiga TItagaki SMiura IYabe HDove Medical PressarticleAntipsychoticProlonged deliriumRenal dysfunctionRetrospective studyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2823-2828 (2017) |
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DOAJ |
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EN |
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Antipsychotic Prolonged delirium Renal dysfunction Retrospective study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Antipsychotic Prolonged delirium Renal dysfunction Retrospective study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Asano S Kunii Y Hoshino H Osakabe Y Shiga T Itagaki S Miura I Yabe H The efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| description |
Satoko Asano, Yasuto Kunii, Hiroshi Hoshino, Yusuke Osakabe, Tetsuya Shiga, Shuntaro Itagaki, Itaru Miura, Hirooki Yabe Department of Neuropsychiatry, School of Medicine Fukushima Medical University, Fukushima, Japan Aim: Delirium is commonly encountered in daily clinical practice. To identify predictors influencing outcomes, we retrospectively examined the characteristics of inpatients with delirium who required psychiatric medication during hospitalization.Methods: We extracted all new inpatients (n=523) consulted for psychiatric symptoms at Fukushima Medical University Hospital between October 2011 and September 2013. We selected 203 inpatients with delirium diagnosed by psychiatrists. We analyzed data from 177 inpatients with delirium who received psychiatric medication. We defined an “early improvement group” in which delirium resolved in ≤3 days after starting psychiatric medication, and a “prolonged group” with delirium lasting for >3 days. Among the 83 inpatients with renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2), we defined an “early improvement group with renal dysfunction” in which delirium resolved in ≤3 days after starting psychiatric medication and a “prolonged group with renal dysfunction” with delirium lasting for >3 days. We then examined differences between groups for different categorical variables.Results: Dose of antipsychotic medication at end point was significantly lower in the prolonged group with renal dysfunction than in the early improvement group with renal dysfunction.Conclusion: The results suggest that maintaining a sufficient dose of antipsychotics from an early stage may prevent prolongation of delirium even in inpatients with renal dysfunction. Keywords: antipsychotic, prolonged delirium, chronic kidney disease, pharmacokinetics |
| format |
article |
| author |
Asano S Kunii Y Hoshino H Osakabe Y Shiga T Itagaki S Miura I Yabe H |
| author_facet |
Asano S Kunii Y Hoshino H Osakabe Y Shiga T Itagaki S Miura I Yabe H |
| author_sort |
Asano S |
| title |
The efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| title_short |
The efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| title_full |
The efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| title_fullStr |
The efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| title_full_unstemmed |
The efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| title_sort |
efficacy of antipsychotics for prolonged delirium with renal dysfunction |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/9b916fb992424d63bb8cfa9ae0811270 |
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