Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

Incorporation of mismatched nucleotides during DNA replication or repair can lead to mutagenesis. Here the authors reveal that DNA ligase can ligate NHEJ intermediates following incorporation of 8-oxodGTP or dGTP opposite T by DNA Polymerase mu (Pol mu) in vitro, which suggests that Pol mu could cau...

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Autores principales:	Melike Çağlayan, Samuel H. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b91fd3a4ead491b98485dbc7c2bb67c
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spelling	oai:doaj.org-article:9b91fd3a4ead491b98485dbc7c2bb67c2021-12-02T17:32:48ZPol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate10.1038/s41467-018-06700-52041-1723https://doaj.org/article/9b91fd3a4ead491b98485dbc7c2bb67c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06700-5https://doaj.org/toc/2041-1723Incorporation of mismatched nucleotides during DNA replication or repair can lead to mutagenesis. Here the authors reveal that DNA ligase can ligate NHEJ intermediates following incorporation of 8-oxodGTP or dGTP opposite T by DNA Polymerase mu (Pol mu) in vitro, which suggests that Pol mu could cause promutagenic mismatches during DSB repair.Melike ÇağlayanSamuel H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melike Çağlayan Samuel H. Wilson Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
description	Incorporation of mismatched nucleotides during DNA replication or repair can lead to mutagenesis. Here the authors reveal that DNA ligase can ligate NHEJ intermediates following incorporation of 8-oxodGTP or dGTP opposite T by DNA Polymerase mu (Pol mu) in vitro, which suggests that Pol mu could cause promutagenic mismatches during DSB repair.
format	article
author	Melike Çağlayan Samuel H. Wilson
author_facet	Melike Çağlayan Samuel H. Wilson
author_sort	Melike Çağlayan
title	Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
title_short	Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
title_full	Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
title_fullStr	Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
title_full_unstemmed	Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate
title_sort	pol μ dgtp mismatch insertion opposite t coupled with ligation reveals promutagenic dna repair intermediate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9b91fd3a4ead491b98485dbc7c2bb67c
work_keys_str_mv	AT melikecaglayan polmdgtpmismatchinsertionoppositetcoupledwithligationrevealspromutagenicdnarepairintermediate AT samuelhwilson polmdgtpmismatchinsertionoppositetcoupledwithligationrevealspromutagenicdnarepairintermediate
_version_	1718380204612648960

Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

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