Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism

Prostate cancer: Combination of natural compounds limits tumor growth Combinations of two molecules found naturally in edible plants synergistically help reduce tumor growth in a mouse model of prostate cancer. Stefano Tiziani and John DiGiovanni from the University of Texas at Austin, and colleague...

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Autores principales:	Alessia Lodi, Achinto Saha, Xiyuan Lu, Bo Wang, Enrique Sentandreu, Meghan Collins, Mikhail G. Kolonin, John DiGiovanni, Stefano Tiziani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9b9548f662804044bd3910e1503c85d8
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spelling	oai:doaj.org-article:9b9548f662804044bd3910e1503c85d82021-12-02T14:22:13ZCombinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism10.1038/s41698-017-0024-z2397-768Xhttps://doaj.org/article/9b9548f662804044bd3910e1503c85d82017-06-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0024-zhttps://doaj.org/toc/2397-768XProstate cancer: Combination of natural compounds limits tumor growth Combinations of two molecules found naturally in edible plants synergistically help reduce tumor growth in a mouse model of prostate cancer. Stefano Tiziani and John DiGiovanni from the University of Texas at Austin, and colleagues screened a library of 142 natural compounds for the effects of each molecule, alone or in combination, on the viability of cells from mouse and human prostate cancer cell lines. Amongst other promising combinations, the researchers identified ursolic acid and curcumin as the most promising combination for inhibiting tumor growth. (These compounds are found naturally in apple peels and turmeric, respectively.) In mice with implanted prostate tumors, the two compounds synergistically reduced tumor volume and weight, while in cell culture the researchers showed that the compound-combination strategy modulated metabolism of a critical amino acid and other cell signaling pathways.Alessia LodiAchinto SahaXiyuan LuBo WangEnrique SentandreuMeghan CollinsMikhail G. KoloninJohn DiGiovanniStefano TizianiNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alessia Lodi Achinto Saha Xiyuan Lu Bo Wang Enrique Sentandreu Meghan Collins Mikhail G. Kolonin John DiGiovanni Stefano Tiziani Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
description	Prostate cancer: Combination of natural compounds limits tumor growth Combinations of two molecules found naturally in edible plants synergistically help reduce tumor growth in a mouse model of prostate cancer. Stefano Tiziani and John DiGiovanni from the University of Texas at Austin, and colleagues screened a library of 142 natural compounds for the effects of each molecule, alone or in combination, on the viability of cells from mouse and human prostate cancer cell lines. Amongst other promising combinations, the researchers identified ursolic acid and curcumin as the most promising combination for inhibiting tumor growth. (These compounds are found naturally in apple peels and turmeric, respectively.) In mice with implanted prostate tumors, the two compounds synergistically reduced tumor volume and weight, while in cell culture the researchers showed that the compound-combination strategy modulated metabolism of a critical amino acid and other cell signaling pathways.
format	article
author	Alessia Lodi Achinto Saha Xiyuan Lu Bo Wang Enrique Sentandreu Meghan Collins Mikhail G. Kolonin John DiGiovanni Stefano Tiziani
author_facet	Alessia Lodi Achinto Saha Xiyuan Lu Bo Wang Enrique Sentandreu Meghan Collins Mikhail G. Kolonin John DiGiovanni Stefano Tiziani
author_sort	Alessia Lodi
title	Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
title_short	Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
title_full	Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
title_fullStr	Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
title_full_unstemmed	Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
title_sort	combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9b9548f662804044bd3910e1503c85d8
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Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism

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