CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation

Abstract This study aimed to investigate the potential biomarkers of vitiligo by evaluating the disease activity and curative effect of autologous cultured pure melanocyte transplantation (CMT) on patients. Altogether, 36patients with stable vitiligo were treated with CMT. Blister fluid samples were...

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Autores principales:	Fuquan Lin, Wenting Hu, Wen Xu, Miaoni Zhou, Ai‑E. Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b957c2d1585434cb8e5461bfbd67b8e
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spelling	oai:doaj.org-article:9b957c2d1585434cb8e5461bfbd67b8e2021-12-02T18:33:47ZCXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation10.1038/s41598-021-97296-22045-2322https://doaj.org/article/9b957c2d1585434cb8e5461bfbd67b8e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97296-2https://doaj.org/toc/2045-2322Abstract This study aimed to investigate the potential biomarkers of vitiligo by evaluating the disease activity and curative effect of autologous cultured pure melanocyte transplantation (CMT) on patients. Altogether, 36patients with stable vitiligo were treated with CMT. Blister fluid samples were collected from patients with stable vitiligo. Patients with active vitiligo were matched with healthy controls. The chemokine levels in the serum and blister fluid samples were measured using Luminex. The curative effect on patients with stable vitiligo was evaluated 6 months after treatment. Treatment responses were defined according to the extent of repigmentation as effective (if 50% or more repigmentation was achieved) or ineffective (if less than 50% or worse repigmentation was achieved). Patients received re-transplantation if the initial treatment was ineffective. The levels of C-X-C motif chemokine ligand (CXCL)9 and CXCL10 in blister fluid samples were significantly lower in stable patients than in active participants. Receiver operating characteristic analysis revealed that the levels of CXCL9 and CXCL10 were sensitive and specific in diagnosing active vitiligo. Further, 65.6% (21/32) of patients who received CMT had effective treatment responses. The high CXCL9 level in the blister fluid was a significant predictor of ineffective treatment responses. The treatment response was significantly enhanced after treatment. Four patients with ineffective treatment responses received anti-inflammatory treatment and re-transplantation. The CXCL9 and CXCL10 levels in the blister fluid were related to the presence of active vitiligo. Also, the CXCL9 level was a predictor of the effectiveness of CMT in treating vitiligo.Fuquan LinWenting HuWen XuMiaoni ZhouAi‑E. XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fuquan Lin Wenting Hu Wen Xu Miaoni Zhou Ai‑E. Xu CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
description	Abstract This study aimed to investigate the potential biomarkers of vitiligo by evaluating the disease activity and curative effect of autologous cultured pure melanocyte transplantation (CMT) on patients. Altogether, 36patients with stable vitiligo were treated with CMT. Blister fluid samples were collected from patients with stable vitiligo. Patients with active vitiligo were matched with healthy controls. The chemokine levels in the serum and blister fluid samples were measured using Luminex. The curative effect on patients with stable vitiligo was evaluated 6 months after treatment. Treatment responses were defined according to the extent of repigmentation as effective (if 50% or more repigmentation was achieved) or ineffective (if less than 50% or worse repigmentation was achieved). Patients received re-transplantation if the initial treatment was ineffective. The levels of C-X-C motif chemokine ligand (CXCL)9 and CXCL10 in blister fluid samples were significantly lower in stable patients than in active participants. Receiver operating characteristic analysis revealed that the levels of CXCL9 and CXCL10 were sensitive and specific in diagnosing active vitiligo. Further, 65.6% (21/32) of patients who received CMT had effective treatment responses. The high CXCL9 level in the blister fluid was a significant predictor of ineffective treatment responses. The treatment response was significantly enhanced after treatment. Four patients with ineffective treatment responses received anti-inflammatory treatment and re-transplantation. The CXCL9 and CXCL10 levels in the blister fluid were related to the presence of active vitiligo. Also, the CXCL9 level was a predictor of the effectiveness of CMT in treating vitiligo.
format	article
author	Fuquan Lin Wenting Hu Wen Xu Miaoni Zhou Ai‑E. Xu
author_facet	Fuquan Lin Wenting Hu Wen Xu Miaoni Zhou Ai‑E. Xu
author_sort	Fuquan Lin
title	CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
title_short	CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
title_full	CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
title_fullStr	CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
title_full_unstemmed	CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
title_sort	cxcl9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b957c2d1585434cb8e5461bfbd67b8e
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CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation

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