Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury

Abstract Cardiac injury among patients with COVID-19 has been reported and is associated with a high risk of mortality, but cardiac injury may not be the leading factor related to death. The factors related to poor prognosis among COVID-19 patients with myocardial injury are still unclear. This stud...

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Autores principales:	Yiyu He, Xiaoxin Zheng, Xiaoyan Li, Xuejun Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9b9ac950dadf48f6bed61288788bc609
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spelling	oai:doaj.org-article:9b9ac950dadf48f6bed61288788bc6092021-12-02T14:22:00ZKey factors leading to fatal outcomes in COVID-19 patients with cardiac injury10.1038/s41598-021-82396-w2045-2322https://doaj.org/article/9b9ac950dadf48f6bed61288788bc6092021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82396-whttps://doaj.org/toc/2045-2322Abstract Cardiac injury among patients with COVID-19 has been reported and is associated with a high risk of mortality, but cardiac injury may not be the leading factor related to death. The factors related to poor prognosis among COVID-19 patients with myocardial injury are still unclear. This study aimed to explore the potential key factors leading to in-hospital death among COVID-19 patients with cardiac injury. This retrospective single-center study was conducted at Renmin Hospital of Wuhan University, from January 20, 2020 to April 10, 2020, in Wuhan, China. All inpatients with confirmed COVID-19 (≥ 18 years old) and cardiac injury who had died or were discharged by April 10, 2020 were included. Demographic data and clinical and laboratory findings were collected and compared between survivors and nonsurvivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with mortality in COVID-19 patients with cardiac injury. A total of 173 COVID-19 patients with cardiac injury were included in this study, 86 were discharged and 87 died in the hospital. Multivariable regression showed increased odds of in-hospital death were associated with advanced age (odds ratio 1.12, 95% CI 1.05–1.18, per year increase; p < 0.001), coagulopathy (2.54, 1.26–5.12; p = 0·009), acute respiratory distress syndrome (16.56, 6.66–41.2; p < 0.001), and elevated hypersensitive troponin I (4.54, 1.79–11.48; p = 0.001). A high risk of in-hospital death was observed among COVID-19 patients with cardiac injury in this study. The factors related to death include advanced age, coagulopathy, acute respiratory distress syndrome and elevated levels of hypersensitive troponin I.Yiyu HeXiaoxin ZhengXiaoyan LiXuejun JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yiyu He Xiaoxin Zheng Xiaoyan Li Xuejun Jiang Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury
description	Abstract Cardiac injury among patients with COVID-19 has been reported and is associated with a high risk of mortality, but cardiac injury may not be the leading factor related to death. The factors related to poor prognosis among COVID-19 patients with myocardial injury are still unclear. This study aimed to explore the potential key factors leading to in-hospital death among COVID-19 patients with cardiac injury. This retrospective single-center study was conducted at Renmin Hospital of Wuhan University, from January 20, 2020 to April 10, 2020, in Wuhan, China. All inpatients with confirmed COVID-19 (≥ 18 years old) and cardiac injury who had died or were discharged by April 10, 2020 were included. Demographic data and clinical and laboratory findings were collected and compared between survivors and nonsurvivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with mortality in COVID-19 patients with cardiac injury. A total of 173 COVID-19 patients with cardiac injury were included in this study, 86 were discharged and 87 died in the hospital. Multivariable regression showed increased odds of in-hospital death were associated with advanced age (odds ratio 1.12, 95% CI 1.05–1.18, per year increase; p < 0.001), coagulopathy (2.54, 1.26–5.12; p = 0·009), acute respiratory distress syndrome (16.56, 6.66–41.2; p < 0.001), and elevated hypersensitive troponin I (4.54, 1.79–11.48; p = 0.001). A high risk of in-hospital death was observed among COVID-19 patients with cardiac injury in this study. The factors related to death include advanced age, coagulopathy, acute respiratory distress syndrome and elevated levels of hypersensitive troponin I.
format	article
author	Yiyu He Xiaoxin Zheng Xiaoyan Li Xuejun Jiang
author_facet	Yiyu He Xiaoxin Zheng Xiaoyan Li Xuejun Jiang
author_sort	Yiyu He
title	Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury
title_short	Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury
title_full	Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury
title_fullStr	Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury
title_full_unstemmed	Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury
title_sort	key factors leading to fatal outcomes in covid-19 patients with cardiac injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b9ac950dadf48f6bed61288788bc609
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Key factors leading to fatal outcomes in COVID-19 patients with cardiac injury

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