Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing transmission of receptor inputs at the cell rear.

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Autores principales:	Amalia Hadjitheodorou, George R. R. Bell, Felix Ellett, Shashank Shastry, Daniel Irimia, Sean R. Collins, Julie A. Theriot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f
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spelling	oai:doaj.org-article:9b9cbbb7074d45fe8ce70da40ca6262f2021-11-21T12:36:28ZDirectional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity10.1038/s41467-021-26622-z2041-1723https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26622-zhttps://doaj.org/toc/2041-1723Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing transmission of receptor inputs at the cell rear.Amalia HadjitheodorouGeorge R. R. BellFelix EllettShashank ShastryDaniel IrimiaSean R. CollinsJulie A. TheriotNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amalia Hadjitheodorou George R. R. Bell Felix Ellett Shashank Shastry Daniel Irimia Sean R. Collins Julie A. Theriot Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
description	Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing transmission of receptor inputs at the cell rear.
format	article
author	Amalia Hadjitheodorou George R. R. Bell Felix Ellett Shashank Shastry Daniel Irimia Sean R. Collins Julie A. Theriot
author_facet	Amalia Hadjitheodorou George R. R. Bell Felix Ellett Shashank Shastry Daniel Irimia Sean R. Collins Julie A. Theriot
author_sort	Amalia Hadjitheodorou
title	Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
title_short	Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
title_full	Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
title_fullStr	Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
title_full_unstemmed	Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
title_sort	directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin ii activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f
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Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity

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