High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.

<h4>Objective</h4>To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province.<h4>Materials and methods</h4>Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoxu Han, Minghui An, Bin Zhao, Song Duan, Shaomin Yang, Junjie Xu, Min Zhang, Jennifer M McGoogan, Yutaka Takebe, Hong Shang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9ba2ef6d97864ab3a7b4afd6e22d84e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ba2ef6d97864ab3a7b4afd6e22d84e4
record_format	dspace
spelling	oai:doaj.org-article:9ba2ef6d97864ab3a7b4afd6e22d84e42021-11-18T07:43:24ZHigh prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.1932-620310.1371/journal.pone.0065337https://doaj.org/article/9ba2ef6d97864ab3a7b4afd6e22d84e42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741489/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province.<h4>Materials and methods</h4>Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 gag, partial pol, vpr-env fragment, half-genome, or near-full-length sequences were analyzed to determine the HIV-1 genotypes of each subject. Results were compared with findings from past studies of IDUs in Dehong and in neighboring Myanmar.<h4>Results</h4>We observed a high prevalence of B'/C recombinants (82.4%) among IDUs in Dehong, the structural profiles of which do not match those previously reported in Dehong or in Myanmar. Furthermore, statistically significant differences in geographical and temporal distributions of HIV-1 genotypes were characterized by a predominance of HIV-1 B'/C recombinant forms among older subjects(p = 0.034), subjects from Longchuan district (p = 0.022), and subjects diagnosed between 2000 and 2004 (p = 0.004).<h4>Conclusions</h4>The increasing prevalence of multiple, new B'/C recombinant forms suggest that HIV-1 intersubtype recombination is substantial and ongoing in western Yunnan. This reflects the high-risk behavior of IDUs in this region and argues the need for stronger monitoring and prevention measures in Dehong and other high-prevalence areas around China.Xiaoxu HanMinghui AnBin ZhaoSong DuanShaomin YangJunjie XuMin ZhangJennifer M McGooganYutaka TakebeHong ShangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e65337 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoxu Han Minghui An Bin Zhao Song Duan Shaomin Yang Junjie Xu Min Zhang Jennifer M McGoogan Yutaka Takebe Hong Shang High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
description	<h4>Objective</h4>To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province.<h4>Materials and methods</h4>Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 gag, partial pol, vpr-env fragment, half-genome, or near-full-length sequences were analyzed to determine the HIV-1 genotypes of each subject. Results were compared with findings from past studies of IDUs in Dehong and in neighboring Myanmar.<h4>Results</h4>We observed a high prevalence of B'/C recombinants (82.4%) among IDUs in Dehong, the structural profiles of which do not match those previously reported in Dehong or in Myanmar. Furthermore, statistically significant differences in geographical and temporal distributions of HIV-1 genotypes were characterized by a predominance of HIV-1 B'/C recombinant forms among older subjects(p = 0.034), subjects from Longchuan district (p = 0.022), and subjects diagnosed between 2000 and 2004 (p = 0.004).<h4>Conclusions</h4>The increasing prevalence of multiple, new B'/C recombinant forms suggest that HIV-1 intersubtype recombination is substantial and ongoing in western Yunnan. This reflects the high-risk behavior of IDUs in this region and argues the need for stronger monitoring and prevention measures in Dehong and other high-prevalence areas around China.
format	article
author	Xiaoxu Han Minghui An Bin Zhao Song Duan Shaomin Yang Junjie Xu Min Zhang Jennifer M McGoogan Yutaka Takebe Hong Shang
author_facet	Xiaoxu Han Minghui An Bin Zhao Song Duan Shaomin Yang Junjie Xu Min Zhang Jennifer M McGoogan Yutaka Takebe Hong Shang
author_sort	Xiaoxu Han
title	High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
title_short	High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
title_full	High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
title_fullStr	High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
title_full_unstemmed	High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
title_sort	high prevalence of hiv-1 intersubtype b'/c recombinants among injecting drug users in dehong, china.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9ba2ef6d97864ab3a7b4afd6e22d84e4
work_keys_str_mv	AT xiaoxuhan highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT minghuian highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT binzhao highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT songduan highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT shaominyang highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT junjiexu highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT minzhang highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT jennifermmcgoogan highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT yutakatakebe highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina AT hongshang highprevalenceofhiv1intersubtypebcrecombinantsamonginjectingdrugusersindehongchina
_version_	1718423051382554624

High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.

Ejemplares similares