Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19

Abstract Background Male androgenetic alopecia (AGA) has been implicated as a putative risk factor in severe COVID‐19 based on high incidences of advanced AGA in male hospitalized COVID‐19 patients. Research further suggests that androgen signalling, which plays a central role in AGA aetiology, prom...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. K. Henne, L. M. Hochfeld, C. Maj, M. M. Nöthen, S. Heilmann‐Heimbach
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/9ba309e23df34bfd82ab692ff2e7e251
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9ba309e23df34bfd82ab692ff2e7e251
record_format	dspace
spelling	oai:doaj.org-article:9ba309e23df34bfd82ab692ff2e7e2512021-12-02T11:13:08ZSystematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐192690-442X10.1002/ski2.72https://doaj.org/article/9ba309e23df34bfd82ab692ff2e7e2512021-12-01T00:00:00Zhttps://doi.org/10.1002/ski2.72https://doaj.org/toc/2690-442XAbstract Background Male androgenetic alopecia (AGA) has been implicated as a putative risk factor in severe COVID‐19 based on high incidences of advanced AGA in male hospitalized COVID‐19 patients. Research further suggests that androgen signalling, which plays a central role in AGA aetiology, promotes SARS‐CoV‐2 infection and is associated with severe COVID‐19 symptoms in men. Objectives We aimed to systematically investigate a potential association between AGA and COVID‐19 both on an epidemiological and a genetic level in a large single‐population cohort. Methods We performed regression, genetic correlation and polygenic risk score (PRS) analyses using data from the UK Biobank and published GWAS data on AGA and COVID‐19. Results Our analyses did not reveal any significant epidemiological or genome‐wide genetic association between AGA and severe COVID‐19. Pathway‐based PRS analyses however revealed a significant association in specific pathways, namely vitamin metabolism, natural killer cell‐mediated cytotoxicity, WNT signalling and aryl hydrocarbon receptor signalling. Limitations We restricted our analyses to the white British population and used self‐reported AGA status. Sample size may be a limitation in our regression and PRS analyses. Conclusions Our data yield no evidence for an epidemiological association between AGA and COVID‐19 but suggest that a shared genetic basis for both traits exists in specific pathways.S. K. HenneL. M. HochfeldC. MajM. M. NöthenS. Heilmann‐HeimbachWileyarticleDermatologyRL1-803ENSkin Health and Disease, Vol 1, Iss 4, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 S. K. Henne L. M. Hochfeld C. Maj M. M. Nöthen S. Heilmann‐Heimbach Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
description	Abstract Background Male androgenetic alopecia (AGA) has been implicated as a putative risk factor in severe COVID‐19 based on high incidences of advanced AGA in male hospitalized COVID‐19 patients. Research further suggests that androgen signalling, which plays a central role in AGA aetiology, promotes SARS‐CoV‐2 infection and is associated with severe COVID‐19 symptoms in men. Objectives We aimed to systematically investigate a potential association between AGA and COVID‐19 both on an epidemiological and a genetic level in a large single‐population cohort. Methods We performed regression, genetic correlation and polygenic risk score (PRS) analyses using data from the UK Biobank and published GWAS data on AGA and COVID‐19. Results Our analyses did not reveal any significant epidemiological or genome‐wide genetic association between AGA and severe COVID‐19. Pathway‐based PRS analyses however revealed a significant association in specific pathways, namely vitamin metabolism, natural killer cell‐mediated cytotoxicity, WNT signalling and aryl hydrocarbon receptor signalling. Limitations We restricted our analyses to the white British population and used self‐reported AGA status. Sample size may be a limitation in our regression and PRS analyses. Conclusions Our data yield no evidence for an epidemiological association between AGA and COVID‐19 but suggest that a shared genetic basis for both traits exists in specific pathways.
format	article
author	S. K. Henne L. M. Hochfeld C. Maj M. M. Nöthen S. Heilmann‐Heimbach
author_facet	S. K. Henne L. M. Hochfeld C. Maj M. M. Nöthen S. Heilmann‐Heimbach
author_sort	S. K. Henne
title	Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
title_short	Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
title_full	Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
title_fullStr	Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
title_full_unstemmed	Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19
title_sort	systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and covid‐19
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/9ba309e23df34bfd82ab692ff2e7e251
work_keys_str_mv	AT skhenne systematicinvestigationofapotentialepidemiologicalandgeneticassociationbetweenmaleandrogeneticalopeciaandcovid19 AT lmhochfeld systematicinvestigationofapotentialepidemiologicalandgeneticassociationbetweenmaleandrogeneticalopeciaandcovid19 AT cmaj systematicinvestigationofapotentialepidemiologicalandgeneticassociationbetweenmaleandrogeneticalopeciaandcovid19 AT mmnothen systematicinvestigationofapotentialepidemiologicalandgeneticassociationbetweenmaleandrogeneticalopeciaandcovid19 AT sheilmannheimbach systematicinvestigationofapotentialepidemiologicalandgeneticassociationbetweenmaleandrogeneticalopeciaandcovid19
_version_	1718396121271762944

Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19

Ejemplares similares