MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.

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Detalles Bibliográficos
Autores principales: Irene Moretti, Stefano Ciciliot, Kenneth A. Dyar, Reimar Abraham, Marta Murgia, Lisa Agatea, Takayuki Akimoto, Silvio Bicciato, Mattia Forcato, Philippe Pierre, N. Henriette Uhlenhaut, Peter W. J. Rigby, Jaime J. Carvajal, Bert Blaauw, Elisa Calabria, Stefano Schiaffino
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/9baf8edc4e774e3bbf5c7edc3c424c25
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Descripción
Sumario:Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.

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