MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.

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Autores principales:	Irene Moretti, Stefano Ciciliot, Kenneth A. Dyar, Reimar Abraham, Marta Murgia, Lisa Agatea, Takayuki Akimoto, Silvio Bicciato, Mattia Forcato, Philippe Pierre, N. Henriette Uhlenhaut, Peter W. J. Rigby, Jaime J. Carvajal, Bert Blaauw, Elisa Calabria, Stefano Schiaffino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9baf8edc4e774e3bbf5c7edc3c424c25
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spelling	oai:doaj.org-article:9baf8edc4e774e3bbf5c7edc3c424c252021-12-02T15:34:30ZMRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity10.1038/ncomms123972041-1723https://doaj.org/article/9baf8edc4e774e3bbf5c7edc3c424c252016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12397https://doaj.org/toc/2041-1723Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.Irene MorettiStefano CiciliotKenneth A. DyarReimar AbrahamMarta MurgiaLisa AgateaTakayuki AkimotoSilvio BicciatoMattia ForcatoPhilippe PierreN. Henriette UhlenhautPeter W. J. RigbyJaime J. CarvajalBert BlaauwElisa CalabriaStefano SchiaffinoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irene Moretti Stefano Ciciliot Kenneth A. Dyar Reimar Abraham Marta Murgia Lisa Agatea Takayuki Akimoto Silvio Bicciato Mattia Forcato Philippe Pierre N. Henriette Uhlenhaut Peter W. J. Rigby Jaime J. Carvajal Bert Blaauw Elisa Calabria Stefano Schiaffino MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
description	Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.
format	article
author	Irene Moretti Stefano Ciciliot Kenneth A. Dyar Reimar Abraham Marta Murgia Lisa Agatea Takayuki Akimoto Silvio Bicciato Mattia Forcato Philippe Pierre N. Henriette Uhlenhaut Peter W. J. Rigby Jaime J. Carvajal Bert Blaauw Elisa Calabria Stefano Schiaffino
author_facet	Irene Moretti Stefano Ciciliot Kenneth A. Dyar Reimar Abraham Marta Murgia Lisa Agatea Takayuki Akimoto Silvio Bicciato Mattia Forcato Philippe Pierre N. Henriette Uhlenhaut Peter W. J. Rigby Jaime J. Carvajal Bert Blaauw Elisa Calabria Stefano Schiaffino
author_sort	Irene Moretti
title	MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
title_short	MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
title_full	MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
title_fullStr	MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
title_full_unstemmed	MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
title_sort	mrf4 negatively regulates adult skeletal muscle growth by repressing mef2 activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9baf8edc4e774e3bbf5c7edc3c424c25
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MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

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