MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/9baf8edc4e774e3bbf5c7edc3c424c25 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|