Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes

Preety Panwar1, Bhumika Pandey1, P C Lakhera2, K P Singh11Biophysics and Nanotechnology Research Laboratory, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India; 2Department of Biotechnology, H.N.B. Garhwal University, Srinagar Garhwal, Uttarakhand, IndiaAbstract:...

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Autores principales:	Preety Panwar, Bhumika Pandey, P C Lakhera, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9bb0714700274a54a7f791aa2c66f56b
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spelling	oai:doaj.org-article:9bb0714700274a54a7f791aa2c66f56b2021-12-02T09:08:48ZPreparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes1176-91141178-2013https://doaj.org/article/9bb0714700274a54a7f791aa2c66f56b2010-02-01T00:00:00Zhttp://www.dovepress.com/preparation-characterization-and-in-vitro-release-study-of-albendazole-a4000https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Preety Panwar1, Bhumika Pandey1, P C Lakhera2, K P Singh11Biophysics and Nanotechnology Research Laboratory, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India; 2Department of Biotechnology, H.N.B. Garhwal University, Srinagar Garhwal, Uttarakhand, IndiaAbstract: The purpose of the present study was to formulate effective and controlled release albendazole liposomal formulations. Albendazole, a hydrophobic drug used for the treatment of hydatid cysts, was encapsulated in nanosize liposomes. Rapid evaporation method was used for the preparation of albendazole-encapsulated conventional and PEGylated liposomes consisting of egg phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (6:4) and PC:CH:polyethylene glycol (PEG) (5:4:1), respectively. In this study, PEGylated and conventional liposomes containing albendazole were prepared and their characteristics, such as particle size, encapsulation efficiency, and in vitro drug release were investigated. The drug encapsulation efficiency of PEGylated and conventional liposomes was 81% and 72%, respectively. The biophysical characterization of both conventional and PEG-coated liposomes were done by transmission electron microscopy and UV-vis spectrophotometry. Efforts were made to study in vitro release of albendazole. The drug release rate showed decrease in albendazole release in descending order: free albendazole, albendazole-loaded conventional liposomes, and least with albendazole-loaded PEG-liposomes. Biologically relevant vesicles were prepared and in vitro release of liposome-entrapped albendazole was determined.Keywords: albendazole, PEGylated, in vitro release, liposomes, nanosize Preety PanwarBhumika PandeyP C Lakheraet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 101-108 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Preety Panwar Bhumika Pandey P C Lakhera et al Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
description	Preety Panwar1, Bhumika Pandey1, P C Lakhera2, K P Singh11Biophysics and Nanotechnology Research Laboratory, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India; 2Department of Biotechnology, H.N.B. Garhwal University, Srinagar Garhwal, Uttarakhand, IndiaAbstract: The purpose of the present study was to formulate effective and controlled release albendazole liposomal formulations. Albendazole, a hydrophobic drug used for the treatment of hydatid cysts, was encapsulated in nanosize liposomes. Rapid evaporation method was used for the preparation of albendazole-encapsulated conventional and PEGylated liposomes consisting of egg phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (6:4) and PC:CH:polyethylene glycol (PEG) (5:4:1), respectively. In this study, PEGylated and conventional liposomes containing albendazole were prepared and their characteristics, such as particle size, encapsulation efficiency, and in vitro drug release were investigated. The drug encapsulation efficiency of PEGylated and conventional liposomes was 81% and 72%, respectively. The biophysical characterization of both conventional and PEG-coated liposomes were done by transmission electron microscopy and UV-vis spectrophotometry. Efforts were made to study in vitro release of albendazole. The drug release rate showed decrease in albendazole release in descending order: free albendazole, albendazole-loaded conventional liposomes, and least with albendazole-loaded PEG-liposomes. Biologically relevant vesicles were prepared and in vitro release of liposome-entrapped albendazole was determined.Keywords: albendazole, PEGylated, in vitro release, liposomes, nanosize
format	article
author	Preety Panwar Bhumika Pandey P C Lakhera et al
author_facet	Preety Panwar Bhumika Pandey P C Lakhera et al
author_sort	Preety Panwar
title	Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
title_short	Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
title_full	Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
title_fullStr	Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
title_full_unstemmed	Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
title_sort	preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/9bb0714700274a54a7f791aa2c66f56b
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Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes

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