ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
The plant Solanum tuberosum is used in Colombian folk medicine for the treatment of hypertension. We evaluated the antiaggregant properties on human platelets of an ethanolic extract (96%) obtained from the skin of tubers of this species. Extracts from two varieties, sabanera and pastusa revealed i...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Universidad de Antioquia
2009
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9bb2904cc5cc45a589d75056a101bb6f |
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| Sumario: | The plant Solanum tuberosum is used in Colombian folk medicine for the treatment of hypertension. We evaluated the antiaggregant properties on human platelets of an ethanolic extract (96%) obtained from the skin of tubers of this species. Extracts from two varieties, sabanera and pastusa revealed in vitro dose-dependent (10–100 mg/mL) antiaggregant effects on platelets stimulated with adenosindiphosphate (ADP 10 μM), epinephrine (300 μM), collagen (10 μg/mL), and arachidonic acid (150 μg/mL). The IC50 values for the sabanera and pastusa varieties were, respectively, 1,8 μg/mL and 0,4 mg/mL, against ADP; 4,4 μg/mL and 0,1 mg/mL against epinephrine; 34,1 μg/mL and 1,3 mg/mL against collagen, and 12,3 μg/mL and < 0,1 μg/mL, against arachidonic acid, a key precursor in
prostaglandin synthesis. Our findings suggest that S. tuberosum has a promising pharmacological profile since it combines the hypotensive effects, previously described, with the antiaggregant ones; therefore, it is potentially useful for the treatment of cardiovascular disorders such as hypertension and coronary artery disease.
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