ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS

The plant Solanum tuberosum is used in Colombian folk medicine for the treatment of hypertension. We evaluated the antiaggregant properties on human platelets of an ethanolic extract (96%) obtained from the skin of tubers of this species. Extracts from two varieties, sabanera and pastusa revealed i...

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Autores principales:	Diana M. BUITRAGO R., Gloria RAMOS R., Javier RINCÓN V., Mario F. GUERRERO P.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Solanum tuberosum arachidonic acid antiaggregant coronary disease. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/9bb2904cc5cc45a589d75056a101bb6f
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spelling	oai:doaj.org-article:9bb2904cc5cc45a589d75056a101bb6f2021-11-19T04:21:37ZANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS0121-40042145-2660https://doaj.org/article/9bb2904cc5cc45a589d75056a101bb6f2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/568https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The plant Solanum tuberosum is used in Colombian folk medicine for the treatment of hypertension. We evaluated the antiaggregant properties on human platelets of an ethanolic extract (96%) obtained from the skin of tubers of this species. Extracts from two varieties, sabanera and pastusa revealed in vitro dose-dependent (10–100 mg/mL) antiaggregant effects on platelets stimulated with adenosindiphosphate (ADP 10 μM), epinephrine (300 μM), collagen (10 μg/mL), and arachidonic acid (150 μg/mL). The IC50 values for the sabanera and pastusa varieties were, respectively, 1,8 μg/mL and 0,4 mg/mL, against ADP; 4,4 μg/mL and 0,1 mg/mL against epinephrine; 34,1 μg/mL and 1,3 mg/mL against collagen, and 12,3 μg/mL and < 0,1 μg/mL, against arachidonic acid, a key precursor in prostaglandin synthesis. Our findings suggest that S. tuberosum has a promising pharmacological profile since it combines the hypotensive effects, previously described, with the antiaggregant ones; therefore, it is potentially useful for the treatment of cardiovascular disorders such as hypertension and coronary artery disease. Diana M. BUITRAGO R.Gloria RAMOS R.Javier RINCÓN V.Mario F. GUERRERO P.Universidad de AntioquiaarticleSolanum tuberosumarachidonic acidantiaggregantcoronary disease.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Solanum tuberosum arachidonic acid antiaggregant coronary disease. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Solanum tuberosum arachidonic acid antiaggregant coronary disease. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana M. BUITRAGO R. Gloria RAMOS R. Javier RINCÓN V. Mario F. GUERRERO P. ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
description	The plant Solanum tuberosum is used in Colombian folk medicine for the treatment of hypertension. We evaluated the antiaggregant properties on human platelets of an ethanolic extract (96%) obtained from the skin of tubers of this species. Extracts from two varieties, sabanera and pastusa revealed in vitro dose-dependent (10–100 mg/mL) antiaggregant effects on platelets stimulated with adenosindiphosphate (ADP 10 μM), epinephrine (300 μM), collagen (10 μg/mL), and arachidonic acid (150 μg/mL). The IC50 values for the sabanera and pastusa varieties were, respectively, 1,8 μg/mL and 0,4 mg/mL, against ADP; 4,4 μg/mL and 0,1 mg/mL against epinephrine; 34,1 μg/mL and 1,3 mg/mL against collagen, and 12,3 μg/mL and < 0,1 μg/mL, against arachidonic acid, a key precursor in prostaglandin synthesis. Our findings suggest that S. tuberosum has a promising pharmacological profile since it combines the hypotensive effects, previously described, with the antiaggregant ones; therefore, it is potentially useful for the treatment of cardiovascular disorders such as hypertension and coronary artery disease.
format	article
author	Diana M. BUITRAGO R. Gloria RAMOS R. Javier RINCÓN V. Mario F. GUERRERO P.
author_facet	Diana M. BUITRAGO R. Gloria RAMOS R. Javier RINCÓN V. Mario F. GUERRERO P.
author_sort	Diana M. BUITRAGO R.
title	ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
title_short	ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
title_full	ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
title_fullStr	ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
title_full_unstemmed	ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS
title_sort	antiaggregant activity of the ethanolic extracts of <i>solanum tuberosum</i> in human platelets
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/9bb2904cc5cc45a589d75056a101bb6f
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ANTIAGGREGANT ACTIVITY OF THE ETHANOLIC EXTRACTS OF <I>Solanum tuberosum</I> IN HUMAN PLATELETS

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