Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

Ulcerative colitis (UC) is a common chronic nonspecific intestinal inflammation of unknown etiology associated with a low cure rate and a high relapse rate. Hair follicle mesenchymal stem cells (HF-MSCs) are a class of pluripotent stem cells that have differentiation potential and strong proliferati...

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Autores principales:	Lin Zhou, Fengjuan Yan, Rui Jiang, Jing Liu, Limin Cai, Yongchen Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/9bb3a55635024bb3be82fe8e1c0c02e6
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id	oai:doaj.org-article:9bb3a55635024bb3be82fe8e1c0c02e6
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spelling	oai:doaj.org-article:9bb3a55635024bb3be82fe8e1c0c02e62021-11-08T02:36:50ZAdministration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats1942-099410.1155/2021/9930187https://doaj.org/article/9bb3a55635024bb3be82fe8e1c0c02e62021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9930187https://doaj.org/toc/1942-0994Ulcerative colitis (UC) is a common chronic nonspecific intestinal inflammation of unknown etiology associated with a low cure rate and a high relapse rate. Hair follicle mesenchymal stem cells (HF-MSCs) are a class of pluripotent stem cells that have differentiation potential and strong proliferation ability. Nuclear factor red system related factor (Nrf-2) is a key factor in the oxidative stress response. Dextran sulfate sodium- (DSS-) induced rat UC models closely mimic human UC in terms of symptoms and histological changes. Animals were divided into five groups, including a healthy group and UC model rats treated with normal saline, Nrf-2, HF-MSCs, or Nrf-2-expressing HF-MSC group. Based on the expression of intestinal stem cells, inflammatory factors, anti-inflammatory factors, and disease activity index scores, Nrf-2-expressing HF-MSCs had the most obvious therapeutic effect under the same treatment regimen. This study provided a new potential clinical treatment option for ulcerative colitis.Lin ZhouFengjuan YanRui JiangJing LiuLimin CaiYongchen WangHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Lin Zhou Fengjuan Yan Rui Jiang Jing Liu Limin Cai Yongchen Wang Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
description	Ulcerative colitis (UC) is a common chronic nonspecific intestinal inflammation of unknown etiology associated with a low cure rate and a high relapse rate. Hair follicle mesenchymal stem cells (HF-MSCs) are a class of pluripotent stem cells that have differentiation potential and strong proliferation ability. Nuclear factor red system related factor (Nrf-2) is a key factor in the oxidative stress response. Dextran sulfate sodium- (DSS-) induced rat UC models closely mimic human UC in terms of symptoms and histological changes. Animals were divided into five groups, including a healthy group and UC model rats treated with normal saline, Nrf-2, HF-MSCs, or Nrf-2-expressing HF-MSC group. Based on the expression of intestinal stem cells, inflammatory factors, anti-inflammatory factors, and disease activity index scores, Nrf-2-expressing HF-MSCs had the most obvious therapeutic effect under the same treatment regimen. This study provided a new potential clinical treatment option for ulcerative colitis.
format	article
author	Lin Zhou Fengjuan Yan Rui Jiang Jing Liu Limin Cai Yongchen Wang
author_facet	Lin Zhou Fengjuan Yan Rui Jiang Jing Liu Limin Cai Yongchen Wang
author_sort	Lin Zhou
title	Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
title_short	Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
title_full	Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
title_fullStr	Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
title_full_unstemmed	Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
title_sort	administration of nrf-2-modified hair-follicle mscs ameliorates dss-induced ulcerative colitis in rats
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/9bb3a55635024bb3be82fe8e1c0c02e6
work_keys_str_mv	AT linzhou administrationofnrf2modifiedhairfolliclemscsamelioratesdssinducedulcerativecolitisinrats AT fengjuanyan administrationofnrf2modifiedhairfolliclemscsamelioratesdssinducedulcerativecolitisinrats AT ruijiang administrationofnrf2modifiedhairfolliclemscsamelioratesdssinducedulcerativecolitisinrats AT jingliu administrationofnrf2modifiedhairfolliclemscsamelioratesdssinducedulcerativecolitisinrats AT limincai administrationofnrf2modifiedhairfolliclemscsamelioratesdssinducedulcerativecolitisinrats AT yongchenwang administrationofnrf2modifiedhairfolliclemscsamelioratesdssinducedulcerativecolitisinrats
_version_	1718443121496293376

Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats

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