Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.

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Auteurs principaux:	Manideep Chavali, Michael Klingener, Alexandros G. Kokkosis, Yury Garkun, Sylwia Felong, Arianna Maffei, Adan Aguirre
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9bb5de1bd6e4464ba36ebf8b3edcb805
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spelling	oai:doaj.org-article:9bb5de1bd6e4464ba36ebf8b3edcb8052021-12-02T15:34:40ZNon-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination10.1038/s41467-017-02440-02041-1723https://doaj.org/article/9bb5de1bd6e4464ba36ebf8b3edcb8052018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02440-0https://doaj.org/toc/2041-1723Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.Manideep ChavaliMichael KlingenerAlexandros G. KokkosisYury GarkunSylwia FelongArianna MaffeiAdan AguirreNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manideep Chavali Michael Klingener Alexandros G. Kokkosis Yury Garkun Sylwia Felong Arianna Maffei Adan Aguirre Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
description	Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.
format	article
author	Manideep Chavali Michael Klingener Alexandros G. Kokkosis Yury Garkun Sylwia Felong Arianna Maffei Adan Aguirre
author_facet	Manideep Chavali Michael Klingener Alexandros G. Kokkosis Yury Garkun Sylwia Felong Arianna Maffei Adan Aguirre
author_sort	Manideep Chavali
title	Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_short	Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_full	Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_fullStr	Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_full_unstemmed	Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_sort	non-canonical wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9bb5de1bd6e4464ba36ebf8b3edcb805
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Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

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