Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.

Guardado en:
Detalles Bibliográficos
Autores principales: Manideep Chavali, Michael Klingener, Alexandros G. Kokkosis, Yury Garkun, Sylwia Felong, Arianna Maffei, Adan Aguirre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/9bb5de1bd6e4464ba36ebf8b3edcb805
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:9bb5de1bd6e4464ba36ebf8b3edcb805
record_format dspace
spelling oai:doaj.org-article:9bb5de1bd6e4464ba36ebf8b3edcb8052021-12-02T15:34:40ZNon-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination10.1038/s41467-017-02440-02041-1723https://doaj.org/article/9bb5de1bd6e4464ba36ebf8b3edcb8052018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02440-0https://doaj.org/toc/2041-1723Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.Manideep ChavaliMichael KlingenerAlexandros G. KokkosisYury GarkunSylwia FelongArianna MaffeiAdan AguirreNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Manideep Chavali
Michael Klingener
Alexandros G. Kokkosis
Yury Garkun
Sylwia Felong
Arianna Maffei
Adan Aguirre
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
description Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.
format article
author Manideep Chavali
Michael Klingener
Alexandros G. Kokkosis
Yury Garkun
Sylwia Felong
Arianna Maffei
Adan Aguirre
author_facet Manideep Chavali
Michael Klingener
Alexandros G. Kokkosis
Yury Garkun
Sylwia Felong
Arianna Maffei
Adan Aguirre
author_sort Manideep Chavali
title Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_short Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_full Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_fullStr Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_full_unstemmed Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_sort non-canonical wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9bb5de1bd6e4464ba36ebf8b3edcb805
work_keys_str_mv AT manideepchavali noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
AT michaelklingener noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
AT alexandrosgkokkosis noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
AT yurygarkun noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
AT sylwiafelong noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
AT ariannamaffei noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
AT adanaguirre noncanonicalwntsignalingregulatesneuralstemcellquiescenceduringhomeostasisandafterdemyelination
_version_ 1718386795570266112

Ejemplares similares