Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives

Elysia K Donovan,1,2 Anand Swaminath1,2 1Department of Oncology, McMaster University, Hamilton, ON, Canada; 2Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, ON, Canada Abstract: Stereotactic body radiation therapy (SBRT) has emerged as a new technology in radiotherapy delivery, allo...

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Autores principales:	Donovan EK, Swaminath A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	non-small cell lung cancer early stage stereotactic radiation quality of life toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9bb637c8d31040fd852f2bb9d83ead55
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spelling	oai:doaj.org-article:9bb637c8d31040fd852f2bb9d83ead552021-12-02T05:35:27ZStereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives1179-2728https://doaj.org/article/9bb637c8d31040fd852f2bb9d83ead552018-03-01T00:00:00Zhttps://www.dovepress.com/stereotactic--body-radiation-therapy-sbrt-in-the-management-of-non-sma-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Elysia K Donovan,1,2 Anand Swaminath1,2 1Department of Oncology, McMaster University, Hamilton, ON, Canada; 2Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, ON, Canada Abstract: Stereotactic body radiation therapy (SBRT) has emerged as a new technology in radiotherapy delivery, allowing for potentially curative treatment in many patients previously felt not to be candidates for radical surgical resection of stage I non-small-cell lung cancer (NSCLC). Several studies have demonstrated very high local control rates using SBRT, and more recent data have suggested overall survival may approach that of surgery in operable patients. However, SBRT is not without unique toxicities, and the balance of toxicity, and effect on patient-reported quality of life need to be considered with respect to oncologic outcomes. We therefore aim to review SBRT in the context of important patient-related factors, including quality of life in several domains (and in comparison to other therapies such as conventional radiation, surgery, or no treatment). We will also describe scenarios in which SBRT may be reasonably offered (i.e. elderly patients and those with severe COPD), and where it may need to be approached with some caution due to increased risks of toxicity (i.e. tumor location, patients with interstitial lung disease). In total, we hope to characterize the physical, emotional, and functional consequences of SBRT, in relation to other management strategies, in order to aid the clinician in deciding whether SBRT is the optimal treatment choice for each patient with early stage NSCLC. Keywords: non-small-cell lung cancer, early stage, stereotactic radiation, quality of life, toxicityDonovan EKSwaminath ADove Medical Pressarticlenon-small cell lung cancerearly stagestereotactic radiationquality of lifetoxicityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 9, Pp 13-23 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-small cell lung cancer early stage stereotactic radiation quality of life toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	non-small cell lung cancer early stage stereotactic radiation quality of life toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Donovan EK Swaminath A Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives
description	Elysia K Donovan,1,2 Anand Swaminath1,2 1Department of Oncology, McMaster University, Hamilton, ON, Canada; 2Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, ON, Canada Abstract: Stereotactic body radiation therapy (SBRT) has emerged as a new technology in radiotherapy delivery, allowing for potentially curative treatment in many patients previously felt not to be candidates for radical surgical resection of stage I non-small-cell lung cancer (NSCLC). Several studies have demonstrated very high local control rates using SBRT, and more recent data have suggested overall survival may approach that of surgery in operable patients. However, SBRT is not without unique toxicities, and the balance of toxicity, and effect on patient-reported quality of life need to be considered with respect to oncologic outcomes. We therefore aim to review SBRT in the context of important patient-related factors, including quality of life in several domains (and in comparison to other therapies such as conventional radiation, surgery, or no treatment). We will also describe scenarios in which SBRT may be reasonably offered (i.e. elderly patients and those with severe COPD), and where it may need to be approached with some caution due to increased risks of toxicity (i.e. tumor location, patients with interstitial lung disease). In total, we hope to characterize the physical, emotional, and functional consequences of SBRT, in relation to other management strategies, in order to aid the clinician in deciding whether SBRT is the optimal treatment choice for each patient with early stage NSCLC. Keywords: non-small-cell lung cancer, early stage, stereotactic radiation, quality of life, toxicity
format	article
author	Donovan EK Swaminath A
author_facet	Donovan EK Swaminath A
author_sort	Donovan EK
title	Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives
title_short	Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives
title_full	Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives
title_fullStr	Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives
title_full_unstemmed	Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives
title_sort	stereotactic body radiation therapy (sbrt) in the management of non-small-cell lung cancer: clinical impact and patient perspectives
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9bb637c8d31040fd852f2bb9d83ead55
work_keys_str_mv	AT donovanek stereotacticbodyradiationtherapysbrtinthemanagementofnonsmallcelllungcancerclinicalimpactandpatientperspectives AT swaminatha stereotacticbodyradiationtherapysbrtinthemanagementofnonsmallcelllungcancerclinicalimpactandpatientperspectives
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Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives

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