EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1

The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are prese...

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Autores principales:	S. V. Sennikov, A. A. Alshevskaya, J. V. Zhukova, I. A. Belomestnova, A. V. Karaulov, J. A. Lopatnikova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	cytokines receptors immunoregulation immunopathology immunotherapy growth factors interleukins interferons tumor necrosis factor Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9bb68a7e582048aba4f968c3bae3ff8e
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spelling	oai:doaj.org-article:9bb68a7e582048aba4f968c3bae3ff8e2021-11-18T08:03:48ZEXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 11563-06252313-741X10.15789/1563-0625-2019-2-209-220https://doaj.org/article/9bb68a7e582048aba4f968c3bae3ff8e2019-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1734https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.S. V. SennikovA. A. AlshevskayaJ. V. ZhukovaI. A. BelomestnovaA. V. KaraulovJ. A. LopatnikovaSPb RAACIarticlecytokinesreceptorsimmunoregulationimmunopathologyimmunotherapygrowth factorsinterleukinsinterferonstumor necrosis factorImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 2, Pp 209-220 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines receptors immunoregulation immunopathology immunotherapy growth factors interleukins interferons tumor necrosis factor Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines receptors immunoregulation immunopathology immunotherapy growth factors interleukins interferons tumor necrosis factor Immunologic diseases. Allergy RC581-607 S. V. Sennikov A. A. Alshevskaya J. V. Zhukova I. A. Belomestnova A. V. Karaulov J. A. Lopatnikova EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1
description	The present review article summarizes the latest world scientific data on the role of receptors for immune mediators in regulating biological effects on the cells. For the main classes of immune regulators (interleukins, interferons, growth factors and tumor necrosis factors), the variants are presented for participation of receptors as components of cytokine/cell interaction, as proven by in vitro and in vivo studies. Ability of the receptors expression to modify characteristics and type of these interactions is shown. The data on participation of receptors for regulatory molecules in development of immune-mediated diseases of various genesis have been analyzed. It was demonstrated that the changes in the receptor expression are of great importance when evaluating functional response of the cells to the mediators and in development of pathological conditions. Current studies confirmed the data suggesting effects of receptor density upon the processes of proliferation and apoptosis, as well as metabolic processes that trigger development of autoimmune, oncological and dystrophic diseases. For all the considered classes of regulatory molecules, the change in the density of receptor expression is one of the key aspects in regulating functional activity of the cells. Thus, studying expression levels of receptors on the cell membrane is important in understanding pathogenesis, whereas changing expression level may be considered as a therapeutic target in the treatment of various diseases.
format	article
author	S. V. Sennikov A. A. Alshevskaya J. V. Zhukova I. A. Belomestnova A. V. Karaulov J. A. Lopatnikova
author_facet	S. V. Sennikov A. A. Alshevskaya J. V. Zhukova I. A. Belomestnova A. V. Karaulov J. A. Lopatnikova
author_sort	S. V. Sennikov
title	EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1
title_short	EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1
title_full	EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1
title_fullStr	EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1
title_full_unstemmed	EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1
title_sort	expression density of receptors to immunoregulatory mediators as a modulating component of biological effects of mediators on cell. part 1
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/9bb68a7e582048aba4f968c3bae3ff8e
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_version_	1718422368638992384

EXPRESSION DENSITY OF RECEPTORS TO IMMUNOREGULATORY MEDIATORS AS A MODULATING COMPONENT OF BIOLOGICAL EFFECTS OF MEDIATORS ON CELL. PART 1

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