Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis

Abstract The goal of this study was to determine the diagnostic performance of in vivo quantitative proton magnetic resonance spectroscopy (1H-MRS) to identify the presence of esophageal varices needing treatment (VNT), as well as investigate its correlation with clinical characteristics in patients...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chung-Man Moon, Yun-Young Lee, Suk-Hee Heo, Sang-Soo Shin, Yong-Yeon Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9bbb517de9944a539d29717fc856556b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9bbb517de9944a539d29717fc856556b
record_format	dspace
spelling	oai:doaj.org-article:9bbb517de9944a539d29717fc856556b2021-12-02T17:13:18ZIdentification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis10.1038/s41598-021-99198-92045-2322https://doaj.org/article/9bbb517de9944a539d29717fc856556b2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99198-9https://doaj.org/toc/2045-2322Abstract The goal of this study was to determine the diagnostic performance of in vivo quantitative proton magnetic resonance spectroscopy (1H-MRS) to identify the presence of esophageal varices needing treatment (VNT), as well as investigate its correlation with clinical characteristics in patients with liver cirrhosis. Forty cirrhotic patients without VNT showing the negative red color sign, and 40 cirrhotic patients with VNT showing positive red color sign underwent laboratory tests, esophago-gastro-duodenoscopy, and 1H-MRS with single-voxel localization in the cirrhotic liver parenchyma. The levels of lactate + triglyceride (TG) and choline in cirrhotic patients with VNT were significantly higher than those in cirrhotic patients without VNT. In multivariate analysis, spleen diameter, platelet count, and platelet count/spleen diameter ratio, as well as lactate + TG, and choline were associated with the presence of VNT. Moreover, lactate + TG and choline levels were positively correlated with spleen diameter and negatively correlated with platelet count in the combined group of cirrhotic patients with and without VNT. Our study demonstrated that higher hepatic lactate + TG and choline levels in cirrhotic patients in conjunction with longer spleen diameter, lower platelet counts, and lower ratios of platelet count to spleen diameter were associated with the presence of esophageal VNT and the risk of developing variceal bleeding. Therefore, in vivo 1H-MRS might be an effective tool for diagnosing and predicting esophageal VNT in patients with liver cirrhosis.Chung-Man MoonYun-Young LeeSuk-Hee HeoSang-Soo ShinYong-Yeon JeongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chung-Man Moon Yun-Young Lee Suk-Hee Heo Sang-Soo Shin Yong-Yeon Jeong Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
description	Abstract The goal of this study was to determine the diagnostic performance of in vivo quantitative proton magnetic resonance spectroscopy (1H-MRS) to identify the presence of esophageal varices needing treatment (VNT), as well as investigate its correlation with clinical characteristics in patients with liver cirrhosis. Forty cirrhotic patients without VNT showing the negative red color sign, and 40 cirrhotic patients with VNT showing positive red color sign underwent laboratory tests, esophago-gastro-duodenoscopy, and 1H-MRS with single-voxel localization in the cirrhotic liver parenchyma. The levels of lactate + triglyceride (TG) and choline in cirrhotic patients with VNT were significantly higher than those in cirrhotic patients without VNT. In multivariate analysis, spleen diameter, platelet count, and platelet count/spleen diameter ratio, as well as lactate + TG, and choline were associated with the presence of VNT. Moreover, lactate + TG and choline levels were positively correlated with spleen diameter and negatively correlated with platelet count in the combined group of cirrhotic patients with and without VNT. Our study demonstrated that higher hepatic lactate + TG and choline levels in cirrhotic patients in conjunction with longer spleen diameter, lower platelet counts, and lower ratios of platelet count to spleen diameter were associated with the presence of esophageal VNT and the risk of developing variceal bleeding. Therefore, in vivo 1H-MRS might be an effective tool for diagnosing and predicting esophageal VNT in patients with liver cirrhosis.
format	article
author	Chung-Man Moon Yun-Young Lee Suk-Hee Heo Sang-Soo Shin Yong-Yeon Jeong
author_facet	Chung-Man Moon Yun-Young Lee Suk-Hee Heo Sang-Soo Shin Yong-Yeon Jeong
author_sort	Chung-Man Moon
title	Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
title_short	Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
title_full	Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
title_fullStr	Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
title_full_unstemmed	Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
title_sort	identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9bbb517de9944a539d29717fc856556b
work_keys_str_mv	AT chungmanmoon identificationofpotentialmetabolicbiomarkersinpredictingesophagealvaricesneedingtreatmentinpatientswithlivercirrhosis AT yunyounglee identificationofpotentialmetabolicbiomarkersinpredictingesophagealvaricesneedingtreatmentinpatientswithlivercirrhosis AT sukheeheo identificationofpotentialmetabolicbiomarkersinpredictingesophagealvaricesneedingtreatmentinpatientswithlivercirrhosis AT sangsooshin identificationofpotentialmetabolicbiomarkersinpredictingesophagealvaricesneedingtreatmentinpatientswithlivercirrhosis AT yongyeonjeong identificationofpotentialmetabolicbiomarkersinpredictingesophagealvaricesneedingtreatmentinpatientswithlivercirrhosis
_version_	1718381334291808256

Identification of potential metabolic biomarkers in predicting esophageal varices needing treatment in patients with liver cirrhosis

Ejemplares similares