Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure

Cancellous bone plays an indispensable role in the skeletal system due to its various functions and high porosity. In this work, chitosan and hydroxyapatite nanowires (CS@HAP NWs) hybrid nanostructured scaffolds with suitable mechanical properties, high porosity and a fine porous structure were prep...

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Autores principales:	He Xia, Lun Dong, Min Hao, Yuan Wei, Jiazhi Duan, Xin Chen, Liyang Yu, Haijun Li, Yuanhua Sang, Hong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bone tissue engineering hydroxyapatite 3D scaffold hADSCs osteogenesis differentiation Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9bbeac2885bb4ed996c4a2650d67cb39
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spelling	oai:doaj.org-article:9bbeac2885bb4ed996c4a2650d67cb392021-11-19T05:50:19ZOsteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure2296-264610.3389/fchem.2021.798299https://doaj.org/article/9bbeac2885bb4ed996c4a2650d67cb392021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.798299/fullhttps://doaj.org/toc/2296-2646Cancellous bone plays an indispensable role in the skeletal system due to its various functions and high porosity. In this work, chitosan and hydroxyapatite nanowires (CS@HAP NWs) hybrid nanostructured scaffolds with suitable mechanical properties, high porosity and a fine porous structure were prepared to simulate the 3-dimensional structure of cancellous bone. The 3D-hybrid scaffolds promote cell adhesion and the migration of human adipose-derived stem cells (hADSCs) inside the scaffolds. The cavities in the scaffolds provide space for the hADSCs proliferation and differentiation. Moreover, the various contents of HAP and the induced mechanical property changes regulate the differentiation of hADSCs toward osteoblasts. Overall, cellular fate regulation of hADSCs via rationally engineered HAP-based hybrid scaffolds is a facile and effective approach for bone tissue engineering.He XiaLun DongMin HaoYuan WeiJiazhi DuanXin ChenLiyang YuHaijun LiYuanhua SangHong LiuFrontiers Media S.A.articlebone tissue engineeringhydroxyapatite3D scaffoldhADSCsosteogenesis differentiationChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone tissue engineering hydroxyapatite 3D scaffold hADSCs osteogenesis differentiation Chemistry QD1-999
spellingShingle	bone tissue engineering hydroxyapatite 3D scaffold hADSCs osteogenesis differentiation Chemistry QD1-999 He Xia Lun Dong Min Hao Yuan Wei Jiazhi Duan Xin Chen Liyang Yu Haijun Li Yuanhua Sang Hong Liu Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
description	Cancellous bone plays an indispensable role in the skeletal system due to its various functions and high porosity. In this work, chitosan and hydroxyapatite nanowires (CS@HAP NWs) hybrid nanostructured scaffolds with suitable mechanical properties, high porosity and a fine porous structure were prepared to simulate the 3-dimensional structure of cancellous bone. The 3D-hybrid scaffolds promote cell adhesion and the migration of human adipose-derived stem cells (hADSCs) inside the scaffolds. The cavities in the scaffolds provide space for the hADSCs proliferation and differentiation. Moreover, the various contents of HAP and the induced mechanical property changes regulate the differentiation of hADSCs toward osteoblasts. Overall, cellular fate regulation of hADSCs via rationally engineered HAP-based hybrid scaffolds is a facile and effective approach for bone tissue engineering.
format	article
author	He Xia Lun Dong Min Hao Yuan Wei Jiazhi Duan Xin Chen Liyang Yu Haijun Li Yuanhua Sang Hong Liu
author_facet	He Xia Lun Dong Min Hao Yuan Wei Jiazhi Duan Xin Chen Liyang Yu Haijun Li Yuanhua Sang Hong Liu
author_sort	He Xia
title	Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
title_short	Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
title_full	Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
title_fullStr	Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
title_full_unstemmed	Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
title_sort	osteogenic property regulation of stem cells by a hydroxyapatite 3d-hybrid scaffold with cancellous bone structure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9bbeac2885bb4ed996c4a2650d67cb39
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Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure

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