MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation

Xiao-Ya Qin,1,2,* Xiao-Xin Liu,1,2,* Zi-Yuan Li,1,2 Li-Ying Guo,1,2 Zhuo-Zhao Zheng,3 Hai-Tao Guan,4 Li Song,4 Ying-Hua Zou,4 Tian-Yuan Fan1,2 1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of Chin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qin XY, Liu XX, Li ZY, Guo LY, Zheng ZZ, Guan HT, Song L, Zou YH, Fan TY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	polymerized microspheres magnetic ferrite nanoclusters magnetic resonance imaging embolization microwave-assisted solvothermal method Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9bbfa28cabaa4082b13e9184cdedd035
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9bbfa28cabaa4082b13e9184cdedd035
record_format	dspace
spelling	oai:doaj.org-article:9bbfa28cabaa4082b13e9184cdedd0352021-12-02T04:48:10ZMRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation1178-2013https://doaj.org/article/9bbfa28cabaa4082b13e9184cdedd0352019-11-01T00:00:00Zhttps://www.dovepress.com/mri-detectable-polymer-microspheres-embedded-with-magnetic-ferrite-nan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiao-Ya Qin,1,2,* Xiao-Xin Liu,1,2,* Zi-Yuan Li,1,2 Li-Ying Guo,1,2 Zhuo-Zhao Zheng,3 Hai-Tao Guan,4 Li Song,4 Ying-Hua Zou,4 Tian-Yuan Fan1,2 1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China; 3Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, Beijing, People’s Republic of China; 4Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tian-Yuan FanDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road No.38, Haidian District, Beijing 100191, People’s Republic of ChinaTel/fax +86 10 8280 5123Email tianyuan_fan@bjmu.edu.cnObjective: The objective of this study was to develop magnetic embolic microspheres that could be visualized by clinical magnetic resonance imaging (MRI) scanners aiming to improve the efficiency and safety of embolotherapy.Methods and discussion: Magnetic ferrite nanoclusters (FNs) were synthesized with microwave-assisted solvothermal method, and their morphology, particle size, crystalline structure, magnetic properties as well as T2 relaxivity were characterized to confirm the feasibility of FNs as an MRI probe. Magnetic polymer microspheres (FNMs) were then produced by inverse suspension polymerization with FNs embedded inside. The physicochemical and mechanical properties (including morphology, particle size, infrared spectra, elasticity, etc.) of FNMs were investigated, and the magnetic properties and MRI detectable properties of FNMs were also assayed by vibrating sample magnetometer and MRI scanners. Favorable biocompatibility and long-term MRI detectability of FNMs were then studied in mice by subcutaneous injection. FNMs were further used to embolize rabbits’ kidneys to evaluate the embolic property and detectability by MRI.Conclusion: FNMs could serve as a promising MRI-visualized embolic material for embolotherapy in the future.Keywords: polymerized microspheres, magnetic ferrite nanoclusters, magnetic resonance imaging, embolization, microwave-assisted solvothermal methodQin XYLiu XXLi ZYGuo LYZheng ZZGuan HTSong LZou YHFan TYDove Medical Pressarticlepolymerized microspheresmagnetic ferrite nanoclustersmagnetic resonance imagingembolizationmicrowave-assisted solvothermal methodMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8989-9006 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymerized microspheres magnetic ferrite nanoclusters magnetic resonance imaging embolization microwave-assisted solvothermal method Medicine (General) R5-920
spellingShingle	polymerized microspheres magnetic ferrite nanoclusters magnetic resonance imaging embolization microwave-assisted solvothermal method Medicine (General) R5-920 Qin XY Liu XX Li ZY Guo LY Zheng ZZ Guan HT Song L Zou YH Fan TY MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation
description	Xiao-Ya Qin,1,2,* Xiao-Xin Liu,1,2,* Zi-Yuan Li,1,2 Li-Ying Guo,1,2 Zhuo-Zhao Zheng,3 Hai-Tao Guan,4 Li Song,4 Ying-Hua Zou,4 Tian-Yuan Fan1,2 1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China; 3Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, Beijing, People’s Republic of China; 4Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tian-Yuan FanDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road No.38, Haidian District, Beijing 100191, People’s Republic of ChinaTel/fax +86 10 8280 5123Email tianyuan_fan@bjmu.edu.cnObjective: The objective of this study was to develop magnetic embolic microspheres that could be visualized by clinical magnetic resonance imaging (MRI) scanners aiming to improve the efficiency and safety of embolotherapy.Methods and discussion: Magnetic ferrite nanoclusters (FNs) were synthesized with microwave-assisted solvothermal method, and their morphology, particle size, crystalline structure, magnetic properties as well as T2 relaxivity were characterized to confirm the feasibility of FNs as an MRI probe. Magnetic polymer microspheres (FNMs) were then produced by inverse suspension polymerization with FNs embedded inside. The physicochemical and mechanical properties (including morphology, particle size, infrared spectra, elasticity, etc.) of FNMs were investigated, and the magnetic properties and MRI detectable properties of FNMs were also assayed by vibrating sample magnetometer and MRI scanners. Favorable biocompatibility and long-term MRI detectability of FNMs were then studied in mice by subcutaneous injection. FNMs were further used to embolize rabbits’ kidneys to evaluate the embolic property and detectability by MRI.Conclusion: FNMs could serve as a promising MRI-visualized embolic material for embolotherapy in the future.Keywords: polymerized microspheres, magnetic ferrite nanoclusters, magnetic resonance imaging, embolization, microwave-assisted solvothermal method
format	article
author	Qin XY Liu XX Li ZY Guo LY Zheng ZZ Guan HT Song L Zou YH Fan TY
author_facet	Qin XY Liu XX Li ZY Guo LY Zheng ZZ Guan HT Song L Zou YH Fan TY
author_sort	Qin XY
title	MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation
title_short	MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation
title_full	MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation
title_fullStr	MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation
title_full_unstemmed	MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation
title_sort	mri detectable polymer microspheres embedded with magnetic ferrite nanoclusters for embolization: in vitro and in vivo evaluation
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9bbfa28cabaa4082b13e9184cdedd035
work_keys_str_mv	AT qinxy mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT liuxx mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT lizy mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT guoly mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT zhengzz mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT guanht mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT songl mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT zouyh mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation AT fanty mridetectablepolymermicrospheresembeddedwithmagneticferritenanoclustersforembolizationinvitroandinvivoevaluation
_version_	1718401026445279232

MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation

Ejemplares similares