Effects of alcohol on skeletal muscle contractile performance in male and female mice.

<h4>Background</h4>Acute and chronic alcohol use can cause skeletal muscle myopathy in concert with impairments in skeletal muscle strength, function and fatigue resistance. However, the fundamental contractile deficits induced in the presence of alcohol versus those observed in the reco...

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Autores principales:	Joseph A Laudato, Abigail L Tice, Jarrod A Call, Bradley S Gordon, Jennifer L Steiner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9bc0a034780d4f3d858bf25eb34ed29f
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spelling	oai:doaj.org-article:9bc0a034780d4f3d858bf25eb34ed29f2021-12-02T20:18:14ZEffects of alcohol on skeletal muscle contractile performance in male and female mice.1932-620310.1371/journal.pone.0255946https://doaj.org/article/9bc0a034780d4f3d858bf25eb34ed29f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255946https://doaj.org/toc/1932-6203<h4>Background</h4>Acute and chronic alcohol use can cause skeletal muscle myopathy in concert with impairments in skeletal muscle strength, function and fatigue resistance. However, the fundamental contractile deficits induced in the presence of alcohol versus those observed in the recovery period following the clearance of alcohol have not yet been characterized nor is it known whether sex influences these outcomes.<h4>Methods</h4>Male and female mice received an intraperitoneal injection of either saline (Control) or ethanol (EtOH; 5g/kg body weight). Muscle force, fatigue, fatigue recovery and twitch characteristics of the posterior crural muscle complex were measured in situ 1 hour and 24 hours post alcohol.<h4>Results</h4>In the presence of alcohol (1-hour post treatment) absolute and normalized force generated at 80-150 Hertz was decreased in male and female mice with concurrent reductions in the rate of force development and increases in ½ relaxation time. When expressed as a percentage of maximum force, both males and females also displayed an alcohol-induced leftward shift in the force frequency curve indicative of a type I contractile phenotype. Alcohol enhanced fatigue in both males and females but had no effect on force recovery. Following clearance of alcohol (24-hour post treatment), contractile function was completely restored in females while alcohol treated males experienced sustained reductions in absolute force and had enhanced fatigue compared with male controls.<h4>Conclusions</h4>In the presence of alcohol, both males and females exhibited significant declines in muscle force production and enhanced fatigue; however, following complete clearance of the alcohol, females recovered all functional parameters, while males did not.Joseph A LaudatoAbigail L TiceJarrod A CallBradley S GordonJennifer L SteinerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255946 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph A Laudato Abigail L Tice Jarrod A Call Bradley S Gordon Jennifer L Steiner Effects of alcohol on skeletal muscle contractile performance in male and female mice.
description	<h4>Background</h4>Acute and chronic alcohol use can cause skeletal muscle myopathy in concert with impairments in skeletal muscle strength, function and fatigue resistance. However, the fundamental contractile deficits induced in the presence of alcohol versus those observed in the recovery period following the clearance of alcohol have not yet been characterized nor is it known whether sex influences these outcomes.<h4>Methods</h4>Male and female mice received an intraperitoneal injection of either saline (Control) or ethanol (EtOH; 5g/kg body weight). Muscle force, fatigue, fatigue recovery and twitch characteristics of the posterior crural muscle complex were measured in situ 1 hour and 24 hours post alcohol.<h4>Results</h4>In the presence of alcohol (1-hour post treatment) absolute and normalized force generated at 80-150 Hertz was decreased in male and female mice with concurrent reductions in the rate of force development and increases in ½ relaxation time. When expressed as a percentage of maximum force, both males and females also displayed an alcohol-induced leftward shift in the force frequency curve indicative of a type I contractile phenotype. Alcohol enhanced fatigue in both males and females but had no effect on force recovery. Following clearance of alcohol (24-hour post treatment), contractile function was completely restored in females while alcohol treated males experienced sustained reductions in absolute force and had enhanced fatigue compared with male controls.<h4>Conclusions</h4>In the presence of alcohol, both males and females exhibited significant declines in muscle force production and enhanced fatigue; however, following complete clearance of the alcohol, females recovered all functional parameters, while males did not.
format	article
author	Joseph A Laudato Abigail L Tice Jarrod A Call Bradley S Gordon Jennifer L Steiner
author_facet	Joseph A Laudato Abigail L Tice Jarrod A Call Bradley S Gordon Jennifer L Steiner
author_sort	Joseph A Laudato
title	Effects of alcohol on skeletal muscle contractile performance in male and female mice.
title_short	Effects of alcohol on skeletal muscle contractile performance in male and female mice.
title_full	Effects of alcohol on skeletal muscle contractile performance in male and female mice.
title_fullStr	Effects of alcohol on skeletal muscle contractile performance in male and female mice.
title_full_unstemmed	Effects of alcohol on skeletal muscle contractile performance in male and female mice.
title_sort	effects of alcohol on skeletal muscle contractile performance in male and female mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9bc0a034780d4f3d858bf25eb34ed29f
work_keys_str_mv	AT josephalaudato effectsofalcoholonskeletalmusclecontractileperformanceinmaleandfemalemice AT abigailltice effectsofalcoholonskeletalmusclecontractileperformanceinmaleandfemalemice AT jarrodacall effectsofalcoholonskeletalmusclecontractileperformanceinmaleandfemalemice AT bradleysgordon effectsofalcoholonskeletalmusclecontractileperformanceinmaleandfemalemice AT jenniferlsteiner effectsofalcoholonskeletalmusclecontractileperformanceinmaleandfemalemice
_version_	1718374298988576768

Effects of alcohol on skeletal muscle contractile performance in male and female mice.

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