MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS

Abstract. The 1044 biopsies from HPV-positive cervical epithelia were tested by cytological, histological, immunomorphological methods and PCR. One of the mechanisms of genesis of cervical cancer is damage of mitotic apparatus owing to association E7 HPV with NuMA 1, leads to infringement of distrib...

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Autor principal:	V. A. Ershov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	hpv integration cervix uteri dysplasia cancer mitosis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9bc1020c579440e89d24627111bd924d
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spelling	oai:doaj.org-article:9bc1020c579440e89d24627111bd924d2021-11-22T07:09:46ZMECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS2220-76192313-739810.15789/2220-7619-2014-2-167-172https://doaj.org/article/9bc1020c579440e89d24627111bd924d2014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/168https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The 1044 biopsies from HPV-positive cervical epithelia were tested by cytological, histological, immunomorphological methods and PCR. One of the mechanisms of genesis of cervical cancer is damage of mitotic apparatus owing to association E7 HPV with NuMA 1, leads to infringement of distribution of chromosomes and virus DNA between daughter cells, shown pathological mitosis and integration of virus DNA. Infringements of differentiation of cells at CIN testified to their delay in pre-mitotic phases of cellular cycle unlike SCC which cells, having finished mitosis, are capable to the differentiation, accompanied by infringement of intercellular adhesion and neoanginesis. Genesis koilocytes and the cells of leukoplakia it is caused by defeat HPV basal cells.V. A. ErshovSankt-Peterburg : NIIÈM imeni Pasteraarticlehpvintegrationcervix uteridysplasiacancermitosisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 2, Pp 167-172 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hpv integration cervix uteri dysplasia cancer mitosis Infectious and parasitic diseases RC109-216
spellingShingle	hpv integration cervix uteri dysplasia cancer mitosis Infectious and parasitic diseases RC109-216 V. A. Ershov MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
description	Abstract. The 1044 biopsies from HPV-positive cervical epithelia were tested by cytological, histological, immunomorphological methods and PCR. One of the mechanisms of genesis of cervical cancer is damage of mitotic apparatus owing to association E7 HPV with NuMA 1, leads to infringement of distribution of chromosomes and virus DNA between daughter cells, shown pathological mitosis and integration of virus DNA. Infringements of differentiation of cells at CIN testified to their delay in pre-mitotic phases of cellular cycle unlike SCC which cells, having finished mitosis, are capable to the differentiation, accompanied by infringement of intercellular adhesion and neoanginesis. Genesis koilocytes and the cells of leukoplakia it is caused by defeat HPV basal cells.
format	article
author	V. A. Ershov
author_facet	V. A. Ershov
author_sort	V. A. Ershov
title	MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
title_short	MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
title_full	MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
title_fullStr	MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
title_full_unstemmed	MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS
title_sort	mechanism of genesis of neoplasia at defeat of cervical epithelium by high-risk human papillomavirus
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/9bc1020c579440e89d24627111bd924d
work_keys_str_mv	AT vaershov mechanismofgenesisofneoplasiaatdefeatofcervicalepitheliumbyhighriskhumanpapillomavirus
_version_	1718418056532721664

MECHANISM OF GENESIS OF NEOPLASIA AT DEFEAT OF CERVICAL EPITHELIUM BY HIGH-RISK HUMAN PAPILLOMAVIRUS

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