Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice

Abstract Coinfection of microorganisms is a common phenomenon in humans and animals. In order to further our understanding of the progress of coinfection and the possible interaction between different pathogens, we have built a coinfection mouse model with Schistosoma japonicum and Salmonella typhim...

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Autores principales:	Xiaoyang Zhu, Lu Chen, Junfang Wu, Huiru Tang, Yulan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9bc15b8155b04e8692913c3d59065313
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spelling	oai:doaj.org-article:9bc15b8155b04e8692913c3d590653132021-12-02T16:06:23ZSalmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice10.1038/s41598-017-00992-12045-2322https://doaj.org/article/9bc15b8155b04e8692913c3d590653132017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00992-1https://doaj.org/toc/2045-2322Abstract Coinfection of microorganisms is a common phenomenon in humans and animals. In order to further our understanding of the progress of coinfection and the possible interaction between different pathogens, we have built a coinfection mouse model with Schistosoma japonicum and Salmonella typhimurium, and used this model to investigate the systemic metabolic and immune responses using NMR-based metabonomics and immunological techniques. Our results show that Salmonella typhimurium (ATCC14028) infection reduces the number of adult schistosomal worms and eggs, relieves symptoms of schistosomiasis and also abates the mortality of mice infected by Schistosoma japonicum. In addition, Salmonella typhimurium infection counteracts the metabolic disturbances associated with schistosomiasis, which was reflected by the reverted levels of metabolites in coinfected mice, compared with the Schistosoma japonicum infected mice. Furthermore, immune analyses also indicate that shift of the immune response to different pathogens is a result of indirect interactions between Schistosoma japonicum and Salmonella typhimurium within the host. Salmonella typhimurium infection can ameliorate Schistosoma japonicum-caused schistosomiasis in BALB/c mice, which is most likely due to inverse immune polarization. Our work provides an insight into coinfection between Schistosoma japonicum and Salmonella typhimurium, and may further contribute to the development of new tools for controlling Schistosoma japonicum-associated diseases.Xiaoyang ZhuLu ChenJunfang WuHuiru TangYulan WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoyang Zhu Lu Chen Junfang Wu Huiru Tang Yulan Wang Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
description	Abstract Coinfection of microorganisms is a common phenomenon in humans and animals. In order to further our understanding of the progress of coinfection and the possible interaction between different pathogens, we have built a coinfection mouse model with Schistosoma japonicum and Salmonella typhimurium, and used this model to investigate the systemic metabolic and immune responses using NMR-based metabonomics and immunological techniques. Our results show that Salmonella typhimurium (ATCC14028) infection reduces the number of adult schistosomal worms and eggs, relieves symptoms of schistosomiasis and also abates the mortality of mice infected by Schistosoma japonicum. In addition, Salmonella typhimurium infection counteracts the metabolic disturbances associated with schistosomiasis, which was reflected by the reverted levels of metabolites in coinfected mice, compared with the Schistosoma japonicum infected mice. Furthermore, immune analyses also indicate that shift of the immune response to different pathogens is a result of indirect interactions between Schistosoma japonicum and Salmonella typhimurium within the host. Salmonella typhimurium infection can ameliorate Schistosoma japonicum-caused schistosomiasis in BALB/c mice, which is most likely due to inverse immune polarization. Our work provides an insight into coinfection between Schistosoma japonicum and Salmonella typhimurium, and may further contribute to the development of new tools for controlling Schistosoma japonicum-associated diseases.
format	article
author	Xiaoyang Zhu Lu Chen Junfang Wu Huiru Tang Yulan Wang
author_facet	Xiaoyang Zhu Lu Chen Junfang Wu Huiru Tang Yulan Wang
author_sort	Xiaoyang Zhu
title	Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
title_short	Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
title_full	Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
title_fullStr	Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
title_full_unstemmed	Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
title_sort	salmonella typhimurium infection reduces schistosoma japonicum worm burden in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9bc15b8155b04e8692913c3d59065313
work_keys_str_mv	AT xiaoyangzhu salmonellatyphimuriuminfectionreducesschistosomajaponicumwormburdeninmice AT luchen salmonellatyphimuriuminfectionreducesschistosomajaponicumwormburdeninmice AT junfangwu salmonellatyphimuriuminfectionreducesschistosomajaponicumwormburdeninmice AT huirutang salmonellatyphimuriuminfectionreducesschistosomajaponicumwormburdeninmice AT yulanwang salmonellatyphimuriuminfectionreducesschistosomajaponicumwormburdeninmice
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Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice

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