Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations

Abstract Obesity is associated with an increased risk of breast cancer in post-menopausal women and decreased risk in pre-menopausal women. Conversely, in BRCA1/2 mutation carriers, pre-menopausal obesity is associated with early-onset breast cancer. Here we show that obese, pre-menopausal BRCA1/2 m...

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Autores principales:	Neil M. Iyengar, Xi Kathy Zhou, Hillary Mendieta, Omar El-Hely, Dilip D. Giri, Lisle Winston, Domenick J. Falcone, Hanhan Wang, Lingsong Meng, Taehoon Ha, Michael Pollak, Monica Morrow, Andrew J. Dannenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9bc77085a3d541aca6d6d81c076de591
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spelling	oai:doaj.org-article:9bc77085a3d541aca6d6d81c076de5912021-12-02T13:15:04ZEffects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations10.1038/s41523-021-00226-82374-4677https://doaj.org/article/9bc77085a3d541aca6d6d81c076de5912021-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00226-8https://doaj.org/toc/2374-4677Abstract Obesity is associated with an increased risk of breast cancer in post-menopausal women and decreased risk in pre-menopausal women. Conversely, in BRCA1/2 mutation carriers, pre-menopausal obesity is associated with early-onset breast cancer. Here we show that obese, pre-menopausal BRCA1/2 mutation carriers have increased levels of aromatase and inflammation in the breast, as occurs in post-menopausal women. In a prospective cohort study of 141 women with germline BRCA1 (n = 74) or BRCA2 (n = 67) mutations, leptin, and aromatase expression were higher in the breast tissue of obese versus lean individuals (P < 0.05). Obesity was associated with breast white adipose tissue inflammation, which correlated with breast aromatase levels (P < 0.01). Circulating C-reactive protein, interleukin-6, and leptin positively correlated with body mass index and breast aromatase levels, whereas negative correlations were observed for adiponectin and sex hormone-binding globulin (P < 0.05). These findings could help explain the increased risk of early-onset breast cancer in obese BRCA1/2 mutation carriers.Neil M. IyengarXi Kathy ZhouHillary MendietaOmar El-HelyDilip D. GiriLisle WinstonDomenick J. FalconeHanhan WangLingsong MengTaehoon HaMichael PollakMonica MorrowAndrew J. DannenbergNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Neil M. Iyengar Xi Kathy Zhou Hillary Mendieta Omar El-Hely Dilip D. Giri Lisle Winston Domenick J. Falcone Hanhan Wang Lingsong Meng Taehoon Ha Michael Pollak Monica Morrow Andrew J. Dannenberg Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
description	Abstract Obesity is associated with an increased risk of breast cancer in post-menopausal women and decreased risk in pre-menopausal women. Conversely, in BRCA1/2 mutation carriers, pre-menopausal obesity is associated with early-onset breast cancer. Here we show that obese, pre-menopausal BRCA1/2 mutation carriers have increased levels of aromatase and inflammation in the breast, as occurs in post-menopausal women. In a prospective cohort study of 141 women with germline BRCA1 (n = 74) or BRCA2 (n = 67) mutations, leptin, and aromatase expression were higher in the breast tissue of obese versus lean individuals (P < 0.05). Obesity was associated with breast white adipose tissue inflammation, which correlated with breast aromatase levels (P < 0.01). Circulating C-reactive protein, interleukin-6, and leptin positively correlated with body mass index and breast aromatase levels, whereas negative correlations were observed for adiponectin and sex hormone-binding globulin (P < 0.05). These findings could help explain the increased risk of early-onset breast cancer in obese BRCA1/2 mutation carriers.
format	article
author	Neil M. Iyengar Xi Kathy Zhou Hillary Mendieta Omar El-Hely Dilip D. Giri Lisle Winston Domenick J. Falcone Hanhan Wang Lingsong Meng Taehoon Ha Michael Pollak Monica Morrow Andrew J. Dannenberg
author_facet	Neil M. Iyengar Xi Kathy Zhou Hillary Mendieta Omar El-Hely Dilip D. Giri Lisle Winston Domenick J. Falcone Hanhan Wang Lingsong Meng Taehoon Ha Michael Pollak Monica Morrow Andrew J. Dannenberg
author_sort	Neil M. Iyengar
title	Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
title_short	Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
title_full	Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
title_fullStr	Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
title_full_unstemmed	Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
title_sort	effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with brca1 or brca2 mutations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9bc77085a3d541aca6d6d81c076de591
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Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations

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