Functional connectome differences in individuals with hallucinations across the psychosis continuum

Abstract Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common...

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Autores principales:	Maya J. L. Schutte, Marc M. Bohlken, Guusje Collin, Lucija Abramovic, Marco P. M. Boks, Wiepke Cahn, Meenakshi Dauwan, Edwin van Dellen, Neeltje E. M. van Haren, Kenneth Hugdahl, Sanne Koops, René C. W. Mandl, Iris E. C. Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9bc923f74f784c3fa696160b7e4da7e1
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spelling	oai:doaj.org-article:9bc923f74f784c3fa696160b7e4da7e12021-12-02T15:23:09ZFunctional connectome differences in individuals with hallucinations across the psychosis continuum10.1038/s41598-020-80657-82045-2322https://doaj.org/article/9bc923f74f784c3fa696160b7e4da7e12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80657-8https://doaj.org/toc/2045-2322Abstract Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P < 0.001 adjusted). Differential effects were observed for bipolar-I disorder patients with hallucinations versus controls, mainly characterized by decreased connectivity between fronto-temporal and fronto-striatal areas (P = 0.012 adjusted). No connectivity alterations were found between bipolar-I disorder patients without hallucinations and controls. Our results support the notion that hallucinations in non-clinical individuals and schizophrenia patients are related to altered interactions between sensory and higher-order cognitive brain regions. However, a different dysconnectivity pattern was observed for bipolar-I disorder patients with hallucinations, which implies a different neural mechanism across the psychosis continuum.Maya J. L. SchutteMarc M. BohlkenGuusje CollinLucija AbramovicMarco P. M. BoksWiepke CahnMeenakshi DauwanEdwin van DellenNeeltje E. M. van HarenKenneth HugdahlSanne KoopsRené C. W. MandlIris E. C. SommerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maya J. L. Schutte Marc M. Bohlken Guusje Collin Lucija Abramovic Marco P. M. Boks Wiepke Cahn Meenakshi Dauwan Edwin van Dellen Neeltje E. M. van Haren Kenneth Hugdahl Sanne Koops René C. W. Mandl Iris E. C. Sommer Functional connectome differences in individuals with hallucinations across the psychosis continuum
description	Abstract Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P < 0.001 adjusted). Differential effects were observed for bipolar-I disorder patients with hallucinations versus controls, mainly characterized by decreased connectivity between fronto-temporal and fronto-striatal areas (P = 0.012 adjusted). No connectivity alterations were found between bipolar-I disorder patients without hallucinations and controls. Our results support the notion that hallucinations in non-clinical individuals and schizophrenia patients are related to altered interactions between sensory and higher-order cognitive brain regions. However, a different dysconnectivity pattern was observed for bipolar-I disorder patients with hallucinations, which implies a different neural mechanism across the psychosis continuum.
format	article
author	Maya J. L. Schutte Marc M. Bohlken Guusje Collin Lucija Abramovic Marco P. M. Boks Wiepke Cahn Meenakshi Dauwan Edwin van Dellen Neeltje E. M. van Haren Kenneth Hugdahl Sanne Koops René C. W. Mandl Iris E. C. Sommer
author_facet	Maya J. L. Schutte Marc M. Bohlken Guusje Collin Lucija Abramovic Marco P. M. Boks Wiepke Cahn Meenakshi Dauwan Edwin van Dellen Neeltje E. M. van Haren Kenneth Hugdahl Sanne Koops René C. W. Mandl Iris E. C. Sommer
author_sort	Maya J. L. Schutte
title	Functional connectome differences in individuals with hallucinations across the psychosis continuum
title_short	Functional connectome differences in individuals with hallucinations across the psychosis continuum
title_full	Functional connectome differences in individuals with hallucinations across the psychosis continuum
title_fullStr	Functional connectome differences in individuals with hallucinations across the psychosis continuum
title_full_unstemmed	Functional connectome differences in individuals with hallucinations across the psychosis continuum
title_sort	functional connectome differences in individuals with hallucinations across the psychosis continuum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9bc923f74f784c3fa696160b7e4da7e1
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_version_	1718387342089125888

Functional connectome differences in individuals with hallucinations across the psychosis continuum

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