Molecular and Mechanical Cues for Somite Periodicity

Somitogenesis refers to the segmentation of the paraxial mesoderm, a tissue located on the back of the embryo, into regularly spaced and sized pieces, i.e., the somites. This periodicity is important to assure, for example, the formation of a functional vertebral column. Prevailing models of somitog...

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Autores principales:	Marta Linde-Medina, Theodoor H. Smit
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	clock and wavefront differential strain scaling somitogenesis vertebral column Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9bce30adbe48427696e0476aa886ce0c
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spelling	oai:doaj.org-article:9bce30adbe48427696e0476aa886ce0c2021-12-01T09:15:59ZMolecular and Mechanical Cues for Somite Periodicity2296-634X10.3389/fcell.2021.753446https://doaj.org/article/9bce30adbe48427696e0476aa886ce0c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.753446/fullhttps://doaj.org/toc/2296-634XSomitogenesis refers to the segmentation of the paraxial mesoderm, a tissue located on the back of the embryo, into regularly spaced and sized pieces, i.e., the somites. This periodicity is important to assure, for example, the formation of a functional vertebral column. Prevailing models of somitogenesis are based on the existence of a gene regulatory network capable of generating a striped pattern of gene expression, which is subsequently translated into periodic tissue boundaries. An alternative view is that the pre-pattern that guides somitogenesis is not chemical, but of a mechanical origin. A striped pattern of mechanical strain can be formed in physically connected tissues expanding at different rates, as it occurs in the embryo. Here we argue that both molecular and mechanical cues could drive somite periodicity and suggest how they could be integrated.Marta Linde-MedinaTheodoor H. SmitTheodoor H. SmitFrontiers Media S.A.articleclock and wavefrontdifferential strainscalingsomitogenesisvertebral columnBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clock and wavefront differential strain scaling somitogenesis vertebral column Biology (General) QH301-705.5
spellingShingle	clock and wavefront differential strain scaling somitogenesis vertebral column Biology (General) QH301-705.5 Marta Linde-Medina Theodoor H. Smit Theodoor H. Smit Molecular and Mechanical Cues for Somite Periodicity
description	Somitogenesis refers to the segmentation of the paraxial mesoderm, a tissue located on the back of the embryo, into regularly spaced and sized pieces, i.e., the somites. This periodicity is important to assure, for example, the formation of a functional vertebral column. Prevailing models of somitogenesis are based on the existence of a gene regulatory network capable of generating a striped pattern of gene expression, which is subsequently translated into periodic tissue boundaries. An alternative view is that the pre-pattern that guides somitogenesis is not chemical, but of a mechanical origin. A striped pattern of mechanical strain can be formed in physically connected tissues expanding at different rates, as it occurs in the embryo. Here we argue that both molecular and mechanical cues could drive somite periodicity and suggest how they could be integrated.
format	article
author	Marta Linde-Medina Theodoor H. Smit Theodoor H. Smit
author_facet	Marta Linde-Medina Theodoor H. Smit Theodoor H. Smit
author_sort	Marta Linde-Medina
title	Molecular and Mechanical Cues for Somite Periodicity
title_short	Molecular and Mechanical Cues for Somite Periodicity
title_full	Molecular and Mechanical Cues for Somite Periodicity
title_fullStr	Molecular and Mechanical Cues for Somite Periodicity
title_full_unstemmed	Molecular and Mechanical Cues for Somite Periodicity
title_sort	molecular and mechanical cues for somite periodicity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9bce30adbe48427696e0476aa886ce0c
work_keys_str_mv	AT martalindemedina molecularandmechanicalcuesforsomiteperiodicity AT theodoorhsmit molecularandmechanicalcuesforsomiteperiodicity AT theodoorhsmit molecularandmechanicalcuesforsomiteperiodicity
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Molecular and Mechanical Cues for Somite Periodicity

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