Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant

Background: Interleukin-6 (IL-6) has been known associated with oxidative stress and endothelial dysfunction, and also has important roles in pathogenesis of preeclampsia. Several studies have demonstrated that there was a significant increase of serum IL-6 levels in preeclamptic compared to normote...

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Autores principales:	Eugenius Phyowai Ganap, Sulchan Sofoewan, Risanto Siswosudarmo
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2018
Materias:	interleukin-6 hellp syndrome preeclampsia normotensive hypertensive disorders Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9bd2c341ff484a9d825790a05734d1f1
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spelling	oai:doaj.org-article:9bd2c341ff484a9d825790a05734d1f12021-11-25T13:16:08ZComparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant2085-15452339-093X10.30659/sainsmed.v9i2.3630https://doaj.org/article/9bd2c341ff484a9d825790a05734d1f12018-12-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/3630https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XBackground: Interleukin-6 (IL-6) has been known associated with oxidative stress and endothelial dysfunction, and also has important roles in pathogenesis of preeclampsia. Several studies have demonstrated that there was a significant increase of serum IL-6 levels in preeclamptic compared to normotensive pregnant women. However, study to evaluate serum IL-6 level in pregnant women with HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome is not well documented yet. This study aims to evaluate serum IL-6 levels between women with HELLP syndrome compared to normotensive pregnant. Methods: The research design was observational cross-sectional study. Samples were recruited consecutively using inclusion and exclusion criteria from emergency department and inpatient wards at Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Serum IL-6 were collected from venous blood sample and measured by enzyme-linked immunoassay (ELISA) method. Independent-samples t-test or Mann-Whitney test was used to compare serum IL-6 values between women with HELLP syndrome and normotensive pregrnancy. A statistical measurement conducted using SPSS IBM Statistics 19® and considered significance when p<0,05. Results: There were 46 subjects, consisted of 23 women with HELLP syndrome and 23 women with normotensive pregnancy. Serum IL-6 level was a mean of 0,11±0,08 pg/mL and 0,15±0,20 pg/mL in women with HELLP syndrome compared to normotensive pregnancy respectively. There was no significant statistical difference between both groups (p=0,17). Conclusion:.The result of this study has shown that no significant difference of serum IL-6 level in HELLP syndrome women compared to normotensive pregnant women.Eugenius Phyowai GanapSulchan SofoewanRisanto SiswosudarmoUniversitas Sultan Agung Semarangarticleinterleukin-6hellp syndromepreeclampsianormotensivehypertensive disordersMedicine (General)R5-920ENSains Medika, Vol 9, Iss 2, Pp 62-66 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	interleukin-6 hellp syndrome preeclampsia normotensive hypertensive disorders Medicine (General) R5-920
spellingShingle	interleukin-6 hellp syndrome preeclampsia normotensive hypertensive disorders Medicine (General) R5-920 Eugenius Phyowai Ganap Sulchan Sofoewan Risanto Siswosudarmo Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant
description	Background: Interleukin-6 (IL-6) has been known associated with oxidative stress and endothelial dysfunction, and also has important roles in pathogenesis of preeclampsia. Several studies have demonstrated that there was a significant increase of serum IL-6 levels in preeclamptic compared to normotensive pregnant women. However, study to evaluate serum IL-6 level in pregnant women with HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome is not well documented yet. This study aims to evaluate serum IL-6 levels between women with HELLP syndrome compared to normotensive pregnant. Methods: The research design was observational cross-sectional study. Samples were recruited consecutively using inclusion and exclusion criteria from emergency department and inpatient wards at Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Serum IL-6 were collected from venous blood sample and measured by enzyme-linked immunoassay (ELISA) method. Independent-samples t-test or Mann-Whitney test was used to compare serum IL-6 values between women with HELLP syndrome and normotensive pregrnancy. A statistical measurement conducted using SPSS IBM Statistics 19® and considered significance when p<0,05. Results: There were 46 subjects, consisted of 23 women with HELLP syndrome and 23 women with normotensive pregnancy. Serum IL-6 level was a mean of 0,11±0,08 pg/mL and 0,15±0,20 pg/mL in women with HELLP syndrome compared to normotensive pregnancy respectively. There was no significant statistical difference between both groups (p=0,17). Conclusion:.The result of this study has shown that no significant difference of serum IL-6 level in HELLP syndrome women compared to normotensive pregnant women.
format	article
author	Eugenius Phyowai Ganap Sulchan Sofoewan Risanto Siswosudarmo
author_facet	Eugenius Phyowai Ganap Sulchan Sofoewan Risanto Siswosudarmo
author_sort	Eugenius Phyowai Ganap
title	Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant
title_short	Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant
title_full	Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant
title_fullStr	Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant
title_full_unstemmed	Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant
title_sort	comparison of serum interleukin-6 (il-6) levels between patients with hellp syndrome versus normotensive pregnant
publisher	Universitas Sultan Agung Semarang
publishDate	2018
url	https://doaj.org/article/9bd2c341ff484a9d825790a05734d1f1
work_keys_str_mv	AT eugeniusphyowaiganap comparisonofseruminterleukin6il6levelsbetweenpatientswithhellpsyndromeversusnormotensivepregnant AT sulchansofoewan comparisonofseruminterleukin6il6levelsbetweenpatientswithhellpsyndromeversusnormotensivepregnant AT risantosiswosudarmo comparisonofseruminterleukin6il6levelsbetweenpatientswithhellpsyndromeversusnormotensivepregnant
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Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant

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