Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia

Abstract Neurodegenerative disorders are characterized by the decline of cognitive function and the progressive loss of memory. The dysfunctions of the cognitive and memory system are closely related to the decreases in brain-derived neurotrophic factor (BDNF) and cAMP response element-binding prote...

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Autores principales:	So-Young Oh, Min Jun Jang, Yun-Hyeok Choi, Hongik Hwang, Hyewhon Rhim, Bonggi Lee, Chun Whan Choi, Min Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9bda5b44eebb46e3837f23724f55b51b
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spelling	oai:doaj.org-article:9bda5b44eebb46e3837f23724f55b51b2021-12-02T17:14:58ZCentral administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia10.1038/s41598-021-88463-62045-2322https://doaj.org/article/9bda5b44eebb46e3837f23724f55b51b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88463-6https://doaj.org/toc/2045-2322Abstract Neurodegenerative disorders are characterized by the decline of cognitive function and the progressive loss of memory. The dysfunctions of the cognitive and memory system are closely related to the decreases in brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) signalings. Ribes fasciculatum, a medicinal plant grown in diverse countries, has been reported to pharmacological effects for autoimmune diseases and aging recently. Here we found that afzelin is a major compound in Ribes fasciculatum. To further examine its neuroprotective effect, the afzelin (100 ng/µl, three times a week) was administered into the third ventricle of the hypothalamus of C57BL/6 mice for one month and scopolamine was injected (i.p.) to these mice to impair cognition and memory before each behavior experiment. The electrophysiology to measure long-term potentiation and behavior tests for cognitive and memory functions were performed followed by investigating related molecular signaling pathways. Chronic administration of afzelin into the brain ameliorated synaptic plasticity and cognitive/memory behaviors in mice given scopolamine. Studies of mice’s hippocampi revealed that the response of afzelin was accountable for the restoration of the cholinergic systems and molecular signal transduction via CREB-BDNF pathways. In conclusion, the central administration of afzelin leads to improved neurocognitive and neuroprotective effects on synaptic plasticity and behaviors partly through the increase in CREB-BDNF signaling.So-Young OhMin Jun JangYun-Hyeok ChoiHongik HwangHyewhon RhimBonggi LeeChun Whan ChoiMin Soo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So-Young Oh Min Jun Jang Yun-Hyeok Choi Hongik Hwang Hyewhon Rhim Bonggi Lee Chun Whan Choi Min Soo Kim Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
description	Abstract Neurodegenerative disorders are characterized by the decline of cognitive function and the progressive loss of memory. The dysfunctions of the cognitive and memory system are closely related to the decreases in brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) signalings. Ribes fasciculatum, a medicinal plant grown in diverse countries, has been reported to pharmacological effects for autoimmune diseases and aging recently. Here we found that afzelin is a major compound in Ribes fasciculatum. To further examine its neuroprotective effect, the afzelin (100 ng/µl, three times a week) was administered into the third ventricle of the hypothalamus of C57BL/6 mice for one month and scopolamine was injected (i.p.) to these mice to impair cognition and memory before each behavior experiment. The electrophysiology to measure long-term potentiation and behavior tests for cognitive and memory functions were performed followed by investigating related molecular signaling pathways. Chronic administration of afzelin into the brain ameliorated synaptic plasticity and cognitive/memory behaviors in mice given scopolamine. Studies of mice’s hippocampi revealed that the response of afzelin was accountable for the restoration of the cholinergic systems and molecular signal transduction via CREB-BDNF pathways. In conclusion, the central administration of afzelin leads to improved neurocognitive and neuroprotective effects on synaptic plasticity and behaviors partly through the increase in CREB-BDNF signaling.
format	article
author	So-Young Oh Min Jun Jang Yun-Hyeok Choi Hongik Hwang Hyewhon Rhim Bonggi Lee Chun Whan Choi Min Soo Kim
author_facet	So-Young Oh Min Jun Jang Yun-Hyeok Choi Hongik Hwang Hyewhon Rhim Bonggi Lee Chun Whan Choi Min Soo Kim
author_sort	So-Young Oh
title	Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
title_short	Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
title_full	Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
title_fullStr	Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
title_full_unstemmed	Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
title_sort	central administration of afzelin extracted from ribes fasciculatum improves cognitive and memory function in a mouse model of dementia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9bda5b44eebb46e3837f23724f55b51b
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Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia

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