Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer

Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer

Objective: Costunolide (Cos) is a sesquiterpene lactone extracted from chicory. Although it possesses anti-tumor effects, the underlying molecular mechanism against gastric cancer cells remains unclear. This study aimed to explore the effect and potential mechanism of Cos on gastric cancer.Methods:...

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Autores principales: Cuixiang Xu, Xiaoyan Huang, Xiaohua Lei, Zhankui Jin, Min Wu, Xiao Liu, Yubin Huang, Xiangrong Zhao, Yue Xiong, Jingying Sun, Xianglong Duan, Jianhua Wang
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
costunolide
apoptosis
autophagy
ROS
Akt/GSK3β
gastric cancer
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/9bde2ec7c0cb479ca087c522191de5d5
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