Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?

Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiolog...

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Autores principales:	Jorge B. Cannata-Andía, Natalia Carrillo-López, Osvaldo D. Messina, Neveen A. T. Hamdy, Sara Panizo, Serge L. Ferrari, on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoporosis vascular calcification mineral bone disorders bone loss bone fractures fracture risk Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/9bdec82e057a4d86a952598e80781662
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spelling	oai:doaj.org-article:9bdec82e057a4d86a952598e807816622021-11-25T18:34:31ZPathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?10.3390/nu131138352072-6643https://doaj.org/article/9bdec82e057a4d86a952598e807816622021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3835https://doaj.org/toc/2072-6643Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Indeed, VC is an active process of calcium and phosphate precipitation that involves the transition of the vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Among the molecules involved in this process, parathyroid hormone (PTH) plays a key role acting through several mechanisms which includes the regulation of the RANK/RANKL/OPG system and the Wnt/ß-catenin pathway, the main pathways for bone resorption and bone formation, respectively. Furthermore, some microRNAs have been implicated as common regulators of bone metabolism, VC, left ventricle hypertrophy and myocardial fibrosis. Elucidating the common mechanisms between ageing; VC and bone loss could help to better understand the potential effects of osteoporosis drugs on the CV system.Jorge B. Cannata-AndíaNatalia Carrillo-LópezOsvaldo D. MessinaNeveen A. T. HamdySara PanizoSerge L. Ferrarion behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular DiseasesMDPI AGarticleosteoporosisvascular calcificationmineral bone disordersbone lossbone fracturesfracture riskNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3835, p 3835 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis vascular calcification mineral bone disorders bone loss bone fractures fracture risk Nutrition. Foods and food supply TX341-641
spellingShingle	osteoporosis vascular calcification mineral bone disorders bone loss bone fractures fracture risk Nutrition. Foods and food supply TX341-641 Jorge B. Cannata-Andía Natalia Carrillo-López Osvaldo D. Messina Neveen A. T. Hamdy Sara Panizo Serge L. Ferrari on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
description	Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Indeed, VC is an active process of calcium and phosphate precipitation that involves the transition of the vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Among the molecules involved in this process, parathyroid hormone (PTH) plays a key role acting through several mechanisms which includes the regulation of the RANK/RANKL/OPG system and the Wnt/ß-catenin pathway, the main pathways for bone resorption and bone formation, respectively. Furthermore, some microRNAs have been implicated as common regulators of bone metabolism, VC, left ventricle hypertrophy and myocardial fibrosis. Elucidating the common mechanisms between ageing; VC and bone loss could help to better understand the potential effects of osteoporosis drugs on the CV system.
format	article
author	Jorge B. Cannata-Andía Natalia Carrillo-López Osvaldo D. Messina Neveen A. T. Hamdy Sara Panizo Serge L. Ferrari on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases
author_facet	Jorge B. Cannata-Andía Natalia Carrillo-López Osvaldo D. Messina Neveen A. T. Hamdy Sara Panizo Serge L. Ferrari on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases
author_sort	Jorge B. Cannata-Andía
title	Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
title_short	Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
title_full	Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
title_fullStr	Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
title_full_unstemmed	Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
title_sort	pathophysiology of vascular calcification and bone loss: linked disorders of ageing?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9bdec82e057a4d86a952598e80781662
work_keys_str_mv	AT jorgebcannataandia pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing AT nataliacarrillolopez pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing AT osvaldodmessina pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing AT neveenathamdy pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing AT sarapanizo pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing AT sergelferrari pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing AT onbehalfoftheinternationalosteoporosisfoundationiofworkinggrouponboneandcardiovasculardiseases pathophysiologyofvascularcalcificationandbonelosslinkeddisordersofageing
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Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?

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