Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila

Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.

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Autores principales:	Valentina Botero, Bethany A. Stanhope, Elizabeth B. Brown, Eliza C. Grenci, Tamara Boto, Scarlet J. Park, Lanikea B. King, Keith R. Murphy, Kenneth J. Colodner, James A. Walker, Alex C. Keene, William W. Ja, Seth M. Tomchik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9bdfedfd53ef4415959b9f694b37b1af
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spelling	oai:doaj.org-article:9bdfedfd53ef4415959b9f694b37b1af2021-12-02T17:01:21ZNeurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila10.1038/s41467-021-24505-x2041-1723https://doaj.org/article/9bdfedfd53ef4415959b9f694b37b1af2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24505-xhttps://doaj.org/toc/2041-1723Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.Valentina BoteroBethany A. StanhopeElizabeth B. BrownEliza C. GrenciTamara BotoScarlet J. ParkLanikea B. KingKeith R. MurphyKenneth J. ColodnerJames A. WalkerAlex C. KeeneWilliam W. JaSeth M. TomchikNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Botero Bethany A. Stanhope Elizabeth B. Brown Eliza C. Grenci Tamara Boto Scarlet J. Park Lanikea B. King Keith R. Murphy Kenneth J. Colodner James A. Walker Alex C. Keene William W. Ja Seth M. Tomchik Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
description	Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.
format	article
author	Valentina Botero Bethany A. Stanhope Elizabeth B. Brown Eliza C. Grenci Tamara Boto Scarlet J. Park Lanikea B. King Keith R. Murphy Kenneth J. Colodner James A. Walker Alex C. Keene William W. Ja Seth M. Tomchik
author_facet	Valentina Botero Bethany A. Stanhope Elizabeth B. Brown Eliza C. Grenci Tamara Boto Scarlet J. Park Lanikea B. King Keith R. Murphy Kenneth J. Colodner James A. Walker Alex C. Keene William W. Ja Seth M. Tomchik
author_sort	Valentina Botero
title	Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
title_short	Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
title_full	Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
title_fullStr	Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
title_full_unstemmed	Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
title_sort	neurofibromin regulates metabolic rate via neuronal mechanisms in drosophila
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9bdfedfd53ef4415959b9f694b37b1af
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Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila

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