Cohesin Mutations Induce Chromatin Conformation Perturbation of the <i>H19</i>/<i>IGF2</i> Imprinted Region and Gene Expression Dysregulation in Cornelia de Lange Syndrome Cell Lines
Traditionally, Cornelia de Lange Syndrome (CdLS) is considered a cohesinopathy caused by constitutive mutations in cohesin complex genes. Cohesin is a major regulator of chromatin architecture, including the formation of chromatin loops at the imprinted <i>IGF2</i>/<i>H19</i>...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9be0c72452a44827a476fce44f08dd98 |
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