Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length

Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/cili...

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Autores principales:	Xiangdong Zheng, Anand Ramani, Komal Soni, Marco Gottardo, Shuangping Zheng, Li Ming Gooi, Wenjing Li, Shan Feng, Aruljothi Mariappan, Arpit Wason, Per Widlund, Andrei Pozniakovsky, Ina Poser, Haiteng Deng, Guangshuo Ou, Maria Riparbelli, Callaini Giuliano, Anthony A. Hyman, Michael Sattler, Jay Gopalakrishnan, Haitao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9be27009a3e84a74ac5a9cc418b64bae
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spelling	oai:doaj.org-article:9be27009a3e84a74ac5a9cc418b64bae2021-12-02T14:40:11ZMolecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length10.1038/ncomms118742041-1723https://doaj.org/article/9be27009a3e84a74ac5a9cc418b64bae2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11874https://doaj.org/toc/2041-1723Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control.Xiangdong ZhengAnand RamaniKomal SoniMarco GottardoShuangping ZhengLi Ming GooiWenjing LiShan FengAruljothi MariappanArpit WasonPer WidlundAndrei PozniakovskyIna PoserHaiteng DengGuangshuo OuMaria RiparbelliCallaini GiulianoAnthony A. HymanMichael SattlerJay GopalakrishnanHaitao LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangdong Zheng Anand Ramani Komal Soni Marco Gottardo Shuangping Zheng Li Ming Gooi Wenjing Li Shan Feng Aruljothi Mariappan Arpit Wason Per Widlund Andrei Pozniakovsky Ina Poser Haiteng Deng Guangshuo Ou Maria Riparbelli Callaini Giuliano Anthony A. Hyman Michael Sattler Jay Gopalakrishnan Haitao Li Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
description	Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control.
format	article
author	Xiangdong Zheng Anand Ramani Komal Soni Marco Gottardo Shuangping Zheng Li Ming Gooi Wenjing Li Shan Feng Aruljothi Mariappan Arpit Wason Per Widlund Andrei Pozniakovsky Ina Poser Haiteng Deng Guangshuo Ou Maria Riparbelli Callaini Giuliano Anthony A. Hyman Michael Sattler Jay Gopalakrishnan Haitao Li
author_facet	Xiangdong Zheng Anand Ramani Komal Soni Marco Gottardo Shuangping Zheng Li Ming Gooi Wenjing Li Shan Feng Aruljothi Mariappan Arpit Wason Per Widlund Andrei Pozniakovsky Ina Poser Haiteng Deng Guangshuo Ou Maria Riparbelli Callaini Giuliano Anthony A. Hyman Michael Sattler Jay Gopalakrishnan Haitao Li
author_sort	Xiangdong Zheng
title	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
title_short	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
title_full	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
title_fullStr	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
title_full_unstemmed	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
title_sort	molecular basis for cpap-tubulin interaction in controlling centriolar and ciliary length
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9be27009a3e84a74ac5a9cc418b64bae
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Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length

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