Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

Abstract RIG-I and MDA5 are cytoplasmic viral RNA sensors that belong to the RIG-I-like receptors (RLRs), which induce antiviral innate immune responses, including the production of type I interferon and other pro-inflammatory cytokines. After recognition of viral RNA, the N-terminal caspase activat...

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Bibliographic Details
Main Authors: Takahisa Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/9be71f73eb1d49e9a5dea918b6fa101c
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