Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural variations within the CTD are functionally important.

Guardado en:

Detalles Bibliográficos
Autores principales:	Bede Portz, Feiyue Lu, Eric B. Gibbs, Joshua E. Mayfield, M. Rachel Mehaffey, Yan Jessie Zhang, Jennifer S. Brodbelt, Scott A. Showalter, David S. Gilmour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9be77a77ce514f7ba76ca8962cfa5211
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9be77a77ce514f7ba76ca8962cfa5211
record_format	dspace
spelling	oai:doaj.org-article:9be77a77ce514f7ba76ca8962cfa52112021-12-02T17:06:15ZStructural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain10.1038/ncomms152312041-1723https://doaj.org/article/9be77a77ce514f7ba76ca8962cfa52112017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15231https://doaj.org/toc/2041-1723The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural variations within the CTD are functionally important.Bede PortzFeiyue LuEric B. GibbsJoshua E. MayfieldM. Rachel MehaffeyYan Jessie ZhangJennifer S. BrodbeltScott A. ShowalterDavid S. GilmourNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bede Portz Feiyue Lu Eric B. Gibbs Joshua E. Mayfield M. Rachel Mehaffey Yan Jessie Zhang Jennifer S. Brodbelt Scott A. Showalter David S. Gilmour Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
description	The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural variations within the CTD are functionally important.
format	article
author	Bede Portz Feiyue Lu Eric B. Gibbs Joshua E. Mayfield M. Rachel Mehaffey Yan Jessie Zhang Jennifer S. Brodbelt Scott A. Showalter David S. Gilmour
author_facet	Bede Portz Feiyue Lu Eric B. Gibbs Joshua E. Mayfield M. Rachel Mehaffey Yan Jessie Zhang Jennifer S. Brodbelt Scott A. Showalter David S. Gilmour
author_sort	Bede Portz
title	Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
title_short	Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
title_full	Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
title_fullStr	Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
title_full_unstemmed	Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
title_sort	structural heterogeneity in the intrinsically disordered rna polymerase ii c-terminal domain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9be77a77ce514f7ba76ca8962cfa5211
work_keys_str_mv	AT bedeportz structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT feiyuelu structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT ericbgibbs structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT joshuaemayfield structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT mrachelmehaffey structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT yanjessiezhang structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT jennifersbrodbelt structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT scottashowalter structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain AT davidsgilmour structuralheterogeneityintheintrinsicallydisorderedrnapolymeraseiicterminaldomain
_version_	1718381689528385536

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Ejemplares similares