T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.

<h4>Background</h4>The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01(E) or the oil-in-water based adjuvant AS02(D) indu...

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Autores principales:	Daniel Ansong, Kwaku P Asante, Johan Vekemans, Sandra K Owusu, Ruth Owusu, Naana A W Brobby, David Dosoo, Alex Osei-Akoto, Kingsley Osei-Kwakye, Emmanuel Asafo-Adjei, Kwadwo O Boahen, Justice Sylverken, George Adjei, David Sambian, Stephen Apanga, Kingsley Kayan, Michel H Janssens, Marc J J Lievens, Aurelie C Olivier, Erik Jongert, Patrice Dubois, Barbara M Savarese, Joe Cohen, Sampson Antwi, Brian M Greenwood, Jennifer A Evans, Tsiri Agbenyega, Philippe J Moris, Seth Owusu-Agyei
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9bed284a434d46c6bccc775ce72665e0
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spelling	oai:doaj.org-article:9bed284a434d46c6bccc775ce72665e02021-11-18T06:55:07ZT cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.1932-620310.1371/journal.pone.0018891https://doaj.org/article/9bed284a434d46c6bccc775ce72665e02011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21556142/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01(E) or the oil-in-water based adjuvant AS02(D) induces P. falciparum circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated with protection in the experimental malaria challenge model in adults.<h4>Methods</h4>This study was designed to evaluate the safety and immunogenicity induced over a 19 month period by three vaccination schedules (0,1-, 0,1,2- and 0,1,7-month) of RTS,S/AS01(E) and RTS,S/AS02(D) in children aged 5-17 months in two research centers in Ghana. Control Rabies vaccine using the 0,1,2-month schedule was used in one of two study sites.<h4>Results</h4>Whole blood antigen stimulation followed by intra-cellular cytokine staining showed RTS,S/AS01(E) induced CSP specific CD4 T cells producing IL-2, TNF-α, and IFN-γ. Higher T cell responses were induced by a 0,1,7-month immunization schedule as compared with a 0,1- or 0,1,2-month schedule. RTS,S/AS01(E) induced higher CD4 T cell responses as compared to RTS,S/AS02(D) when given on a 0,1,7-month schedule.<h4>Conclusions</h4>These findings support further Phase III evaluation of RTS,S/AS01(E). The role of immune effectors and immunization schedules on vaccine protection are currently under evaluation.<h4>Trial registration</h4>ClinicalTrials.gov NCT00360230.Daniel AnsongKwaku P AsanteJohan VekemansSandra K OwusuRuth OwusuNaana A W BrobbyDavid DosooAlex Osei-AkotoKingsley Osei-KwakyeEmmanuel Asafo-AdjeiKwadwo O BoahenJustice SylverkenGeorge AdjeiDavid SambianStephen ApangaKingsley KayanMichel H JanssensMarc J J LievensAurelie C OlivierErik JongertPatrice DuboisBarbara M SavareseJoe CohenSampson AntwiBrian M GreenwoodJennifer A EvansTsiri AgbenyegaPhilippe J MorisSeth Owusu-AgyeiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18891 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Ansong Kwaku P Asante Johan Vekemans Sandra K Owusu Ruth Owusu Naana A W Brobby David Dosoo Alex Osei-Akoto Kingsley Osei-Kwakye Emmanuel Asafo-Adjei Kwadwo O Boahen Justice Sylverken George Adjei David Sambian Stephen Apanga Kingsley Kayan Michel H Janssens Marc J J Lievens Aurelie C Olivier Erik Jongert Patrice Dubois Barbara M Savarese Joe Cohen Sampson Antwi Brian M Greenwood Jennifer A Evans Tsiri Agbenyega Philippe J Moris Seth Owusu-Agyei T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
description	<h4>Background</h4>The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01(E) or the oil-in-water based adjuvant AS02(D) induces P. falciparum circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated with protection in the experimental malaria challenge model in adults.<h4>Methods</h4>This study was designed to evaluate the safety and immunogenicity induced over a 19 month period by three vaccination schedules (0,1-, 0,1,2- and 0,1,7-month) of RTS,S/AS01(E) and RTS,S/AS02(D) in children aged 5-17 months in two research centers in Ghana. Control Rabies vaccine using the 0,1,2-month schedule was used in one of two study sites.<h4>Results</h4>Whole blood antigen stimulation followed by intra-cellular cytokine staining showed RTS,S/AS01(E) induced CSP specific CD4 T cells producing IL-2, TNF-α, and IFN-γ. Higher T cell responses were induced by a 0,1,7-month immunization schedule as compared with a 0,1- or 0,1,2-month schedule. RTS,S/AS01(E) induced higher CD4 T cell responses as compared to RTS,S/AS02(D) when given on a 0,1,7-month schedule.<h4>Conclusions</h4>These findings support further Phase III evaluation of RTS,S/AS01(E). The role of immune effectors and immunization schedules on vaccine protection are currently under evaluation.<h4>Trial registration</h4>ClinicalTrials.gov NCT00360230.
format	article
author	Daniel Ansong Kwaku P Asante Johan Vekemans Sandra K Owusu Ruth Owusu Naana A W Brobby David Dosoo Alex Osei-Akoto Kingsley Osei-Kwakye Emmanuel Asafo-Adjei Kwadwo O Boahen Justice Sylverken George Adjei David Sambian Stephen Apanga Kingsley Kayan Michel H Janssens Marc J J Lievens Aurelie C Olivier Erik Jongert Patrice Dubois Barbara M Savarese Joe Cohen Sampson Antwi Brian M Greenwood Jennifer A Evans Tsiri Agbenyega Philippe J Moris Seth Owusu-Agyei
author_facet	Daniel Ansong Kwaku P Asante Johan Vekemans Sandra K Owusu Ruth Owusu Naana A W Brobby David Dosoo Alex Osei-Akoto Kingsley Osei-Kwakye Emmanuel Asafo-Adjei Kwadwo O Boahen Justice Sylverken George Adjei David Sambian Stephen Apanga Kingsley Kayan Michel H Janssens Marc J J Lievens Aurelie C Olivier Erik Jongert Patrice Dubois Barbara M Savarese Joe Cohen Sampson Antwi Brian M Greenwood Jennifer A Evans Tsiri Agbenyega Philippe J Moris Seth Owusu-Agyei
author_sort	Daniel Ansong
title	T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
title_short	T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
title_full	T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
title_fullStr	T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
title_full_unstemmed	T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
title_sort	t cell responses to the rts,s/as01(e) and rts,s/as02(d) malaria candidate vaccines administered according to different schedules to ghanaian children.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9bed284a434d46c6bccc775ce72665e0
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T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.

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