Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies

Introduction The aim of the study was to assess the association of elevated serum pregnancy associated plasma protein A (PAPP-A) and the risk of all-cause mortality, cardiovascular events and mortality due to infection in patients with chronic kidney disease (CKD). Material and methods We systemati...

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Autores principales:	Yuehua Li, Xv Meng, Chenghui Zhou, Xianliang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	chronic kidney disease meta-analysis all-cause mortality pregnancy associated plasma protein a pregnancy-associated plasma protein a Medicine R
Acceso en línea:	https://doaj.org/article/9bef6185c51d49348421e7fe351190ef
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spelling	oai:doaj.org-article:9bef6185c51d49348421e7fe351190ef2021-12-02T18:39:10ZPregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies1734-19221896-915110.5114/aoms.2020.91283https://doaj.org/article/9bef6185c51d49348421e7fe351190ef2019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Pregnancy-associated-plasma-protein-A-as-a-predictor-of-all-cause-mortality-and-cardiovascular,75926,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of the study was to assess the association of elevated serum pregnancy associated plasma protein A (PAPP-A) and the risk of all-cause mortality, cardiovascular events and mortality due to infection in patients with chronic kidney disease (CKD). Material and methods We systematically searched the Medline database up to March 2017. A random effects model was used to pool the relative risks (RRs) and their 95% confidence intervals (CIs). Sensitivity analysis and subgroup analysis were performed to explore the potential sources of heterogeneity. Results Six studies involving 2034 subjects were included. The pooled RRs for the risk of all-cause mortality and cardiovascular events were 1.50 (95% CI: 1.17–1.92), 1.26 (95% CI: 0.95–1.69), respectively. Sensitivity analysis by excluding each individual study showed no influence on the main results. Subgroup analysis showed that age, male proportion, follow-up term, and assay methods were not modifiable factors. Conclusions Our study suggests that elevated serum PAPP-A is associated with the risk of all-cause mortality in patients with CKD.Yuehua LiXv MengChenghui ZhouXianliang ZhouTermedia Publishing Housearticlechronic kidney diseasemeta-analysisall-cause mortalitypregnancy associated plasma protein apregnancy-associated plasma protein aMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 8-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease meta-analysis all-cause mortality pregnancy associated plasma protein a pregnancy-associated plasma protein a Medicine R
spellingShingle	chronic kidney disease meta-analysis all-cause mortality pregnancy associated plasma protein a pregnancy-associated plasma protein a Medicine R Yuehua Li Xv Meng Chenghui Zhou Xianliang Zhou Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
description	Introduction The aim of the study was to assess the association of elevated serum pregnancy associated plasma protein A (PAPP-A) and the risk of all-cause mortality, cardiovascular events and mortality due to infection in patients with chronic kidney disease (CKD). Material and methods We systematically searched the Medline database up to March 2017. A random effects model was used to pool the relative risks (RRs) and their 95% confidence intervals (CIs). Sensitivity analysis and subgroup analysis were performed to explore the potential sources of heterogeneity. Results Six studies involving 2034 subjects were included. The pooled RRs for the risk of all-cause mortality and cardiovascular events were 1.50 (95% CI: 1.17–1.92), 1.26 (95% CI: 0.95–1.69), respectively. Sensitivity analysis by excluding each individual study showed no influence on the main results. Subgroup analysis showed that age, male proportion, follow-up term, and assay methods were not modifiable factors. Conclusions Our study suggests that elevated serum PAPP-A is associated with the risk of all-cause mortality in patients with CKD.
format	article
author	Yuehua Li Xv Meng Chenghui Zhou Xianliang Zhou
author_facet	Yuehua Li Xv Meng Chenghui Zhou Xianliang Zhou
author_sort	Yuehua Li
title	Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
title_short	Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
title_full	Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
title_fullStr	Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
title_full_unstemmed	Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
title_sort	pregnancy-associated plasma protein a as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/9bef6185c51d49348421e7fe351190ef
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Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies

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