Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

How microglia contribute to brain injury or repair is unclear. Here combining microglia manipulations and calcium imaging, the authors show that selective elimination of microglia leads to disrupted neuronal calcium dynamics and markedly increased brain injury after cerebral ischemia.

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Autores principales:	Gergely Szalay, Bernadett Martinecz, Nikolett Lénárt, Zsuzsanna Környei, Barbara Orsolits, Linda Judák, Eszter Császár, Rebeka Fekete, Brian L. West, Gergely Katona, Balázs Rózsa, Ádám Dénes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9bfaf3e021e14db6b290d94b1ef5a607
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spelling	oai:doaj.org-article:9bfaf3e021e14db6b290d94b1ef5a6072021-12-02T17:32:07ZMicroglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke10.1038/ncomms114992041-1723https://doaj.org/article/9bfaf3e021e14db6b290d94b1ef5a6072016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11499https://doaj.org/toc/2041-1723How microglia contribute to brain injury or repair is unclear. Here combining microglia manipulations and calcium imaging, the authors show that selective elimination of microglia leads to disrupted neuronal calcium dynamics and markedly increased brain injury after cerebral ischemia.Gergely SzalayBernadett MartineczNikolett LénártZsuzsanna KörnyeiBarbara OrsolitsLinda JudákEszter CsászárRebeka FeketeBrian L. WestGergely KatonaBalázs RózsaÁdám DénesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gergely Szalay Bernadett Martinecz Nikolett Lénárt Zsuzsanna Környei Barbara Orsolits Linda Judák Eszter Császár Rebeka Fekete Brian L. West Gergely Katona Balázs Rózsa Ádám Dénes Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
description	How microglia contribute to brain injury or repair is unclear. Here combining microglia manipulations and calcium imaging, the authors show that selective elimination of microglia leads to disrupted neuronal calcium dynamics and markedly increased brain injury after cerebral ischemia.
format	article
author	Gergely Szalay Bernadett Martinecz Nikolett Lénárt Zsuzsanna Környei Barbara Orsolits Linda Judák Eszter Császár Rebeka Fekete Brian L. West Gergely Katona Balázs Rózsa Ádám Dénes
author_facet	Gergely Szalay Bernadett Martinecz Nikolett Lénárt Zsuzsanna Környei Barbara Orsolits Linda Judák Eszter Császár Rebeka Fekete Brian L. West Gergely Katona Balázs Rózsa Ádám Dénes
author_sort	Gergely Szalay
title	Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
title_short	Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
title_full	Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
title_fullStr	Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
title_full_unstemmed	Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
title_sort	microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9bfaf3e021e14db6b290d94b1ef5a607
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Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

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