Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or t...
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2018
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oai:doaj.org-article:9c01b2d7a03c4b53b30d257bedbede9c2021-12-02T16:49:18ZCrystal structure of lipid A disaccharide synthase LpxB from Escherichia coli10.1038/s41467-017-02712-92041-1723https://doaj.org/article/9c01b2d7a03c4b53b30d257bedbede9c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02712-9https://doaj.org/toc/2041-1723LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or the membrane.Thomas E. BohlKe ShiJohn K. LeeHideki AiharaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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Science Q Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli |
description |
LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or the membrane. |
format |
article |
author |
Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara |
author_facet |
Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara |
author_sort |
Thomas E. Bohl |
title |
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli |
title_short |
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli |
title_full |
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli |
title_fullStr |
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli |
title_full_unstemmed |
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli |
title_sort |
crystal structure of lipid a disaccharide synthase lpxb from escherichia coli |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/9c01b2d7a03c4b53b30d257bedbede9c |
work_keys_str_mv |
AT thomasebohl crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli AT keshi crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli AT johnklee crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli AT hidekiaihara crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli |
_version_ |
1718383350669901824 |