Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli

LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or t...

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Auteurs principaux:	Thomas E. Bohl, Ke Shi, John K. Lee, Hideki Aihara
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9c01b2d7a03c4b53b30d257bedbede9c
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spelling	oai:doaj.org-article:9c01b2d7a03c4b53b30d257bedbede9c2021-12-02T16:49:18ZCrystal structure of lipid A disaccharide synthase LpxB from Escherichia coli10.1038/s41467-017-02712-92041-1723https://doaj.org/article/9c01b2d7a03c4b53b30d257bedbede9c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02712-9https://doaj.org/toc/2041-1723LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or the membrane.Thomas E. BohlKe ShiJohn K. LeeHideki AiharaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
description	LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or the membrane.
format	article
author	Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara
author_facet	Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara
author_sort	Thomas E. Bohl
title	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_short	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_full	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_fullStr	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_full_unstemmed	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_sort	crystal structure of lipid a disaccharide synthase lpxb from escherichia coli
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c01b2d7a03c4b53b30d257bedbede9c
work_keys_str_mv	AT thomasebohl crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli AT keshi crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli AT johnklee crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli AT hidekiaihara crystalstructureoflipidadisaccharidesynthaselpxbfromescherichiacoli
_version_	1718383350669901824

Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli

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