Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

Abstract Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (B...

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Autores principales:	Ntsiki M. Held, M. Renate Buijink, Hyung L. Elfrink, Sander Kooijman, Georges E. Janssens, Angela C. M. Luyf, Mia L. Pras-Raves, Frédéric M. Vaz, Stephan Michel, Riekelt H. Houtkooper, Michel van Weeghel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c02010f9abc4c868131db2f81cf7e9b
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spelling	oai:doaj.org-article:9c02010f9abc4c868131db2f81cf7e9b2021-12-02T13:17:42ZAging selectively dampens oscillation of lipid abundance in white and brown adipose tissue10.1038/s41598-021-85455-42045-2322https://doaj.org/article/9c02010f9abc4c868131db2f81cf7e9b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85455-4https://doaj.org/toc/2045-2322Abstract Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.Ntsiki M. HeldM. Renate BuijinkHyung L. ElfrinkSander KooijmanGeorges E. JanssensAngela C. M. LuyfMia L. Pras-RavesFrédéric M. VazStephan MichelRiekelt H. HoutkooperMichel van WeeghelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ntsiki M. Held M. Renate Buijink Hyung L. Elfrink Sander Kooijman Georges E. Janssens Angela C. M. Luyf Mia L. Pras-Raves Frédéric M. Vaz Stephan Michel Riekelt H. Houtkooper Michel van Weeghel Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
description	Abstract Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.
format	article
author	Ntsiki M. Held M. Renate Buijink Hyung L. Elfrink Sander Kooijman Georges E. Janssens Angela C. M. Luyf Mia L. Pras-Raves Frédéric M. Vaz Stephan Michel Riekelt H. Houtkooper Michel van Weeghel
author_facet	Ntsiki M. Held M. Renate Buijink Hyung L. Elfrink Sander Kooijman Georges E. Janssens Angela C. M. Luyf Mia L. Pras-Raves Frédéric M. Vaz Stephan Michel Riekelt H. Houtkooper Michel van Weeghel
author_sort	Ntsiki M. Held
title	Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
title_short	Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
title_full	Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
title_fullStr	Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
title_full_unstemmed	Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
title_sort	aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c02010f9abc4c868131db2f81cf7e9b
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Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

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