A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis

Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, contr...

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Autores principales: Tsveta S. Malinova, Ana Angulo-Urarte, Julian Nüchel, Marina Tauber, Miesje M. van der Stoel, Vera Janssen, Annett de Haan, Anouk G. Groenen, Merel Tebbens, Mariona Graupera, Markus Plomann, Stephan Huveneers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9c03eff830ca43ef9a69c069eaae2835
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Sumario:Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.