A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis

A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis

Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, contr...

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Autores principales: Tsveta S. Malinova, Ana Angulo-Urarte, Julian Nüchel, Marina Tauber, Miesje M. van der Stoel, Vera Janssen, Annett de Haan, Anouk G. Groenen, Merel Tebbens, Mariona Graupera, Markus Plomann, Stephan Huveneers
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9c03eff830ca43ef9a69c069eaae2835
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spelling oai:doaj.org-article:9c03eff830ca43ef9a69c069eaae28352021-12-02T15:36:11ZA junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis10.1038/s41467-021-22873-y2041-1723https://doaj.org/article/9c03eff830ca43ef9a69c069eaae28352021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22873-yhttps://doaj.org/toc/2041-1723Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.Tsveta S. MalinovaAna Angulo-UrarteJulian NüchelMarina TauberMiesje M. van der StoelVera JanssenAnnett de HaanAnouk G. GroenenMerel TebbensMariona GrauperaMarkus PlomannStephan HuveneersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tsveta S. Malinova
Ana Angulo-Urarte
Julian Nüchel
Marina Tauber
Miesje M. van der Stoel
Vera Janssen
Annett de Haan
Anouk G. Groenen
Merel Tebbens
Mariona Graupera
Markus Plomann
Stephan Huveneers
A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
description Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.
format article
author Tsveta S. Malinova
Ana Angulo-Urarte
Julian Nüchel
Marina Tauber
Miesje M. van der Stoel
Vera Janssen
Annett de Haan
Anouk G. Groenen
Merel Tebbens
Mariona Graupera
Markus Plomann
Stephan Huveneers
author_facet Tsveta S. Malinova
Ana Angulo-Urarte
Julian Nüchel
Marina Tauber
Miesje M. van der Stoel
Vera Janssen
Annett de Haan
Anouk G. Groenen
Merel Tebbens
Mariona Graupera
Markus Plomann
Stephan Huveneers
author_sort Tsveta S. Malinova
title A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
title_short A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
title_full A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
title_fullStr A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
title_full_unstemmed A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
title_sort junctional pacsin2/ehd4/mical-l1 complex coordinates ve-cadherin trafficking for endothelial migration and angiogenesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/9c03eff830ca43ef9a69c069eaae2835
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