Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens

Abstract Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO–CuO nanocomposites from C. gigantea against non-M...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	G Ambarasan Govindasamy, Rabiatul Basria S. M. N. Mydin, Srimala Sreekantan, Nor Hazliana Harun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c04adda8ab9473aa617d1fbe1e1d7ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9c04adda8ab9473aa617d1fbe1e1d7ff
record_format	dspace
spelling	oai:doaj.org-article:9c04adda8ab9473aa617d1fbe1e1d7ff2021-12-02T11:46:07ZCompositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens10.1038/s41598-020-79547-w2045-2322https://doaj.org/article/9c04adda8ab9473aa617d1fbe1e1d7ff2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79547-whttps://doaj.org/toc/2045-2322Abstract Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO–CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus and Escherichia coli) and MDR (Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin-resistant S. aureus) skin pathogens. Scanning electron microscopy and transmission electron microscopy revealed the size and shape of B3Z1C sample. Results of X-ray powder diffraction, energy-dispersive spectroscopy, FTIR and UV–Vis spectroscopy analyses confirmed the presence of mixed nanoparticles (i.e., zinc oxide, copper oxide, carbon and calcium) and the stabilising phytochemical agents of plant (i.e., phenol and carbonyl). Antimicrobial results showed that carbon and calcium decorated binary ZnO–CuO nanocomposites with compositions of 75 wt% of ZnO and 25 wt% CuO (B3Z1C) was a strong bactericidal agent with the MBC/MIC ratio of ≤ 4 and ≤ 2 for non-MDR and MDR pathogens, respectively. A significant non-MDR zone of inhibitions were observed for BZC by Kirby–Bauer disc-diffusion test. Further time-kill observation revealed significant fourfold reduction in non-MDR pathogen viable count after 12 h study period. Further molecular studies are needed to explain the biocidal mechanism underlying B3Z1C potential.G Ambarasan GovindasamyRabiatul Basria S. M. N. MydinSrimala SreekantanNor Hazliana HarunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q G Ambarasan Govindasamy Rabiatul Basria S. M. N. Mydin Srimala Sreekantan Nor Hazliana Harun Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens
description	Abstract Calotropis gigantea (C. gigantea) extract with an ecofriendly nanotechnology approach could provide promising antimicrobial activity against skin pathogens. This study investigates the antimicrobial capability of green synthesized binary ZnO–CuO nanocomposites from C. gigantea against non-MDR (Staphylococcus aureus and Escherichia coli) and MDR (Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin-resistant S. aureus) skin pathogens. Scanning electron microscopy and transmission electron microscopy revealed the size and shape of B3Z1C sample. Results of X-ray powder diffraction, energy-dispersive spectroscopy, FTIR and UV–Vis spectroscopy analyses confirmed the presence of mixed nanoparticles (i.e., zinc oxide, copper oxide, carbon and calcium) and the stabilising phytochemical agents of plant (i.e., phenol and carbonyl). Antimicrobial results showed that carbon and calcium decorated binary ZnO–CuO nanocomposites with compositions of 75 wt% of ZnO and 25 wt% CuO (B3Z1C) was a strong bactericidal agent with the MBC/MIC ratio of ≤ 4 and ≤ 2 for non-MDR and MDR pathogens, respectively. A significant non-MDR zone of inhibitions were observed for BZC by Kirby–Bauer disc-diffusion test. Further time-kill observation revealed significant fourfold reduction in non-MDR pathogen viable count after 12 h study period. Further molecular studies are needed to explain the biocidal mechanism underlying B3Z1C potential.
format	article
author	G Ambarasan Govindasamy Rabiatul Basria S. M. N. Mydin Srimala Sreekantan Nor Hazliana Harun
author_facet	G Ambarasan Govindasamy Rabiatul Basria S. M. N. Mydin Srimala Sreekantan Nor Hazliana Harun
author_sort	G Ambarasan Govindasamy
title	Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens
title_short	Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens
title_full	Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens
title_fullStr	Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens
title_full_unstemmed	Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens
title_sort	compositions and antimicrobial properties of binary zno–cuo nanocomposites encapsulated calcium and carbon from calotropis gigantea targeted for skin pathogens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c04adda8ab9473aa617d1fbe1e1d7ff
work_keys_str_mv	AT gambarasangovindasamy compositionsandantimicrobialpropertiesofbinaryznocuonanocompositesencapsulatedcalciumandcarbonfromcalotropisgiganteatargetedforskinpathogens AT rabiatulbasriasmnmydin compositionsandantimicrobialpropertiesofbinaryznocuonanocompositesencapsulatedcalciumandcarbonfromcalotropisgiganteatargetedforskinpathogens AT srimalasreekantan compositionsandantimicrobialpropertiesofbinaryznocuonanocompositesencapsulatedcalciumandcarbonfromcalotropisgiganteatargetedforskinpathogens AT norhazlianaharun compositionsandantimicrobialpropertiesofbinaryznocuonanocompositesencapsulatedcalciumandcarbonfromcalotropisgiganteatargetedforskinpathogens
_version_	1718395242912153600

Compositions and antimicrobial properties of binary ZnO–CuO nanocomposites encapsulated calcium and carbon from Calotropis gigantea targeted for skin pathogens

Ejemplares similares