GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also associated with longer telomeres.

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Autores principales:	Ake T. Lu, Luting Xue, Elias L. Salfati, Brian H. Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M. Murabito, Douglas P. Kiel, Pei-Chien Tsai, Idil Yet, Jordana T. Bell, Massimo Mangino, Toshiko Tanaka, Allan F. McRae, Riccardo E. Marioni, Peter M. Visscher, Naomi R. Wray, Ian J. Deary, Morgan E. Levine, Austin Quach, Themistocles Assimes, Philip S. Tsao, Devin Absher, James D. Stewart, Yun Li, Alex P. Reiner, Lifang Hou, Andrea A. Baccarelli, Eric A. Whitsel, Abraham Aviv, Alexia Cardona, Felix R. Day, Nicholas J. Wareham, John R. B. Perry, Ken K. Ong, Kenneth Raj, Kathryn L. Lunetta, Steve Horvath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c04cc5045d14339bb52c91c1cd6b779
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spelling	oai:doaj.org-article:9c04cc5045d14339bb52c91c1cd6b7792021-12-02T15:33:41ZGWAS of epigenetic aging rates in blood reveals a critical role for TERT10.1038/s41467-017-02697-52041-1723https://doaj.org/article/9c04cc5045d14339bb52c91c1cd6b7792018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02697-5https://doaj.org/toc/2041-1723Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also associated with longer telomeres.Ake T. LuLuting XueElias L. SalfatiBrian H. ChenLuigi FerrucciDaniel LevyRoby JoehanesJoanne M. MurabitoDouglas P. KielPei-Chien TsaiIdil YetJordana T. BellMassimo ManginoToshiko TanakaAllan F. McRaeRiccardo E. MarioniPeter M. VisscherNaomi R. WrayIan J. DearyMorgan E. LevineAustin QuachThemistocles AssimesPhilip S. TsaoDevin AbsherJames D. StewartYun LiAlex P. ReinerLifang HouAndrea A. BaccarelliEric A. WhitselAbraham AvivAlexia CardonaFelix R. DayNicholas J. WarehamJohn R. B. PerryKen K. OngKenneth RajKathryn L. LunettaSteve HorvathNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ake T. Lu Luting Xue Elias L. Salfati Brian H. Chen Luigi Ferrucci Daniel Levy Roby Joehanes Joanne M. Murabito Douglas P. Kiel Pei-Chien Tsai Idil Yet Jordana T. Bell Massimo Mangino Toshiko Tanaka Allan F. McRae Riccardo E. Marioni Peter M. Visscher Naomi R. Wray Ian J. Deary Morgan E. Levine Austin Quach Themistocles Assimes Philip S. Tsao Devin Absher James D. Stewart Yun Li Alex P. Reiner Lifang Hou Andrea A. Baccarelli Eric A. Whitsel Abraham Aviv Alexia Cardona Felix R. Day Nicholas J. Wareham John R. B. Perry Ken K. Ong Kenneth Raj Kathryn L. Lunetta Steve Horvath GWAS of epigenetic aging rates in blood reveals a critical role for TERT
description	Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also associated with longer telomeres.
format	article
author	Ake T. Lu Luting Xue Elias L. Salfati Brian H. Chen Luigi Ferrucci Daniel Levy Roby Joehanes Joanne M. Murabito Douglas P. Kiel Pei-Chien Tsai Idil Yet Jordana T. Bell Massimo Mangino Toshiko Tanaka Allan F. McRae Riccardo E. Marioni Peter M. Visscher Naomi R. Wray Ian J. Deary Morgan E. Levine Austin Quach Themistocles Assimes Philip S. Tsao Devin Absher James D. Stewart Yun Li Alex P. Reiner Lifang Hou Andrea A. Baccarelli Eric A. Whitsel Abraham Aviv Alexia Cardona Felix R. Day Nicholas J. Wareham John R. B. Perry Ken K. Ong Kenneth Raj Kathryn L. Lunetta Steve Horvath
author_facet	Ake T. Lu Luting Xue Elias L. Salfati Brian H. Chen Luigi Ferrucci Daniel Levy Roby Joehanes Joanne M. Murabito Douglas P. Kiel Pei-Chien Tsai Idil Yet Jordana T. Bell Massimo Mangino Toshiko Tanaka Allan F. McRae Riccardo E. Marioni Peter M. Visscher Naomi R. Wray Ian J. Deary Morgan E. Levine Austin Quach Themistocles Assimes Philip S. Tsao Devin Absher James D. Stewart Yun Li Alex P. Reiner Lifang Hou Andrea A. Baccarelli Eric A. Whitsel Abraham Aviv Alexia Cardona Felix R. Day Nicholas J. Wareham John R. B. Perry Ken K. Ong Kenneth Raj Kathryn L. Lunetta Steve Horvath
author_sort	Ake T. Lu
title	GWAS of epigenetic aging rates in blood reveals a critical role for TERT
title_short	GWAS of epigenetic aging rates in blood reveals a critical role for TERT
title_full	GWAS of epigenetic aging rates in blood reveals a critical role for TERT
title_fullStr	GWAS of epigenetic aging rates in blood reveals a critical role for TERT
title_full_unstemmed	GWAS of epigenetic aging rates in blood reveals a critical role for TERT
title_sort	gwas of epigenetic aging rates in blood reveals a critical role for tert
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9c04cc5045d14339bb52c91c1cd6b779
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GWAS of epigenetic aging rates in blood reveals a critical role for TERT

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