New drugs for pharmacological extension of replicative life span in normal and progeroid cells

Remedies to extend life span Two drugs were discovered that can extend the life spans of normally aged human cells and thus potentially slow human aging. The anti-aging drugs were identified using a novel method that screens drugs across a two-dimensional endpoint space of senescence-associated gala...

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Autores principales:	Sergei Vatolin, Tomas Radivoyevitch, Jaroslaw P. Maciejewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9c055e12b3344276a5e2f3bd5ccd0cf9
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spelling	oai:doaj.org-article:9c055e12b3344276a5e2f3bd5ccd0cf92021-12-02T14:18:31ZNew drugs for pharmacological extension of replicative life span in normal and progeroid cells10.1038/s41514-018-0032-42056-3973https://doaj.org/article/9c055e12b3344276a5e2f3bd5ccd0cf92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0032-4https://doaj.org/toc/2056-3973Remedies to extend life span Two drugs were discovered that can extend the life spans of normally aged human cells and thus potentially slow human aging. The anti-aging drugs were identified using a novel method that screens drugs across a two-dimensional endpoint space of senescence-associated galactosidase activity as a general axis of aging and ATP as an axis representing proliferation. The two most potent substances were, likely more than coincidentally, electrons carriers that transfer electrons from NAD(P)H to molecules and cellular structures that demand reducing power to repair oxidative damage that accumulates with aging. Treatment of single cells and whole organisms with these new anti-aging drugs increased their lifespans. The mechanism of the drug action may advance our understanding of the complex, yet resolvable, biological process of aging.Sergei VatolinTomas RadivoyevitchJaroslaw P. MaciejewskiNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Sergei Vatolin Tomas Radivoyevitch Jaroslaw P. Maciejewski New drugs for pharmacological extension of replicative life span in normal and progeroid cells
description	Remedies to extend life span Two drugs were discovered that can extend the life spans of normally aged human cells and thus potentially slow human aging. The anti-aging drugs were identified using a novel method that screens drugs across a two-dimensional endpoint space of senescence-associated galactosidase activity as a general axis of aging and ATP as an axis representing proliferation. The two most potent substances were, likely more than coincidentally, electrons carriers that transfer electrons from NAD(P)H to molecules and cellular structures that demand reducing power to repair oxidative damage that accumulates with aging. Treatment of single cells and whole organisms with these new anti-aging drugs increased their lifespans. The mechanism of the drug action may advance our understanding of the complex, yet resolvable, biological process of aging.
format	article
author	Sergei Vatolin Tomas Radivoyevitch Jaroslaw P. Maciejewski
author_facet	Sergei Vatolin Tomas Radivoyevitch Jaroslaw P. Maciejewski
author_sort	Sergei Vatolin
title	New drugs for pharmacological extension of replicative life span in normal and progeroid cells
title_short	New drugs for pharmacological extension of replicative life span in normal and progeroid cells
title_full	New drugs for pharmacological extension of replicative life span in normal and progeroid cells
title_fullStr	New drugs for pharmacological extension of replicative life span in normal and progeroid cells
title_full_unstemmed	New drugs for pharmacological extension of replicative life span in normal and progeroid cells
title_sort	new drugs for pharmacological extension of replicative life span in normal and progeroid cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9c055e12b3344276a5e2f3bd5ccd0cf9
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New drugs for pharmacological extension of replicative life span in normal and progeroid cells

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