Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas

Abstract The objective of this study is to assess prognostic value of surgery for elderly oral tongue squamous cell carcinomas (OTSCC) patients. Patients with OTSCC were extracted from the SEER database between 2010 and 2014. The distributions of categorical demographic and clinicopathological chara...

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Autores principales:	Yujiao Li, Chu Chu, Chaosu Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9c05f0daba044bffac7340c7da24eaf7
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spelling	oai:doaj.org-article:9c05f0daba044bffac7340c7da24eaf72021-12-02T17:05:11ZEffects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas10.1038/s41598-021-85647-y2045-2322https://doaj.org/article/9c05f0daba044bffac7340c7da24eaf72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85647-yhttps://doaj.org/toc/2045-2322Abstract The objective of this study is to assess prognostic value of surgery for elderly oral tongue squamous cell carcinomas (OTSCC) patients. Patients with OTSCC were extracted from the SEER database between 2010 and 2014. The distributions of categorical demographic and clinicopathological characteristics were determined for different age groups: the 75–79, 80–84, and 85–102 years old groups. Univariate and multivariate analyses were performed to determine the effects of each variable on survival. A total of 1064 patients were analyzed. 75–79 years old patients tended to be male and rate of surgery declined with advancing age (P < 0.001). 75–79 years old patients more frequently presented with advanced stage compared to their older peers (P = 0.002). Compared to surgery groups, the hazard ratios for no surgery groups were 2.856 (95% CI 2.267–3.599; (P < 0.001)) for OS and 3.687 (95% CI 2.561–5.308; (P < 0.001)) for CSS in multivariable analysis. In subgroup analysis, the effect of no surgery was significantly associated with a higher risk of poor CSS in patients aged 75–79 years, 80–84 years and 85–102 years (P < 0.001, respectively). Our results showed that there were a series of factors contributing to poor outcomes in the elderly OTSCC patients, including clinicopathological characteristics and surgical management. Surgical resection is significantly associated with an improved OS and CSS, but further exploration in larger prospective clinical trials and better prognostic and predictive tools for select old patients for surgery are needed.Yujiao LiChu ChuChaosu HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yujiao Li Chu Chu Chaosu Hu Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
description	Abstract The objective of this study is to assess prognostic value of surgery for elderly oral tongue squamous cell carcinomas (OTSCC) patients. Patients with OTSCC were extracted from the SEER database between 2010 and 2014. The distributions of categorical demographic and clinicopathological characteristics were determined for different age groups: the 75–79, 80–84, and 85–102 years old groups. Univariate and multivariate analyses were performed to determine the effects of each variable on survival. A total of 1064 patients were analyzed. 75–79 years old patients tended to be male and rate of surgery declined with advancing age (P < 0.001). 75–79 years old patients more frequently presented with advanced stage compared to their older peers (P = 0.002). Compared to surgery groups, the hazard ratios for no surgery groups were 2.856 (95% CI 2.267–3.599; (P < 0.001)) for OS and 3.687 (95% CI 2.561–5.308; (P < 0.001)) for CSS in multivariable analysis. In subgroup analysis, the effect of no surgery was significantly associated with a higher risk of poor CSS in patients aged 75–79 years, 80–84 years and 85–102 years (P < 0.001, respectively). Our results showed that there were a series of factors contributing to poor outcomes in the elderly OTSCC patients, including clinicopathological characteristics and surgical management. Surgical resection is significantly associated with an improved OS and CSS, but further exploration in larger prospective clinical trials and better prognostic and predictive tools for select old patients for surgery are needed.
format	article
author	Yujiao Li Chu Chu Chaosu Hu
author_facet	Yujiao Li Chu Chu Chaosu Hu
author_sort	Yujiao Li
title	Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
title_short	Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
title_full	Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
title_fullStr	Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
title_full_unstemmed	Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
title_sort	effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c05f0daba044bffac7340c7da24eaf7
work_keys_str_mv	AT yujiaoli effectsofsurgeryonsurvivalofpatientsaged75yearsorolderwithoraltonguesquamouscellcarcinomas AT chuchu effectsofsurgeryonsurvivalofpatientsaged75yearsorolderwithoraltonguesquamouscellcarcinomas AT chaosuhu effectsofsurgeryonsurvivalofpatientsaged75yearsorolderwithoraltonguesquamouscellcarcinomas
_version_	1718381804851822592

Effects of surgery on survival of patients aged 75 years or older with oral tongue squamous cell carcinomas

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